Phenotypic characterization and cardiovascular outcomes of patients with familial hypercholesterolemia
department or school: Medicine, Faculty of
department or school: Pathology and Laboratory Medicine, Department of
data provider: DSpace
degree campus: UBCV
creator: Allard, Matthew
issued: 2013-10-21T18:39:35Z
issued: 2013
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Background: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder caused by mutations in the low-density lipoprotein (LDL) receptor, apolipoprotein B-100 gene, or proprotein convertase subtilisin/kexin type 9, resulting in very high blood cholesterol levels and premature cardiovascular disease (CVD). Hypotheses/ Objectives: 1. FH patients who have developed CVD differ from those free of CVD by specific risk factors. 2. The specific risk factors differ in FH patients who develop CVD early and those resistant to CVD 3. These risk factors risk factors differ between men and women. 4. These risk factors differ between ethnic groups. Methods: A retrospective chart review of patients in the Prevention Clinic was carried out to find individuals with “definite” FH according to the Dutch Lipid Clinic Network Criteria (DLCNC) and to determine which patients developed CVD. Cox proportional hazard regression analysis was used to assess the association of risk factors to hard cardiovascular outcomes in univariate and multivariate analyses. Results: A total of 446 patients were identified as having “definite” FH based upon the DLCNC with 116 (26%) patients having hard evidence of CVD. Male sex, smoking, family history of premature CVD, diabetes mellitus, low HDL-C and high Lp(a) proved to be significant, independent risk factors for CVD in the entire FH cohort. The same risk factors remained significant when comparing FH patients susceptible to CVD to those resistant to CVD. Of note, LDL-C and hypertension were not important risk factors for CVD in this cohort. In men, family history, diabetes and low levels of HDL-C were significant risk factors for CVD while in women smoking, diabetes mellitus, low levels of HDL-C and high Lp(a) were significant risk factors for CVD. There were minimal detectable differences in risk factors between ethnicities. Conclusion: In our ethnically diverse cohort the significant risk factors for CVD in decreasing order of importanc…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/45312
note: Phenotypic ?Characterization ?and ?Cardiovascular ?Outcomes ?of ?Patients ?with ?Familial ?Hypercholesterolemia ?by ? ?Matthew ?Allard ? B.K., ?The ?University ?of ?British ?Columbia, ?2011 ? ?A ?THESIS ?SUBMITTED ?IN ?PARTIAL ?FULFILLMENT ?OF ?THE ?REQUIREMENTS ?FOR ?THE ?DEGREE ?OF ? ?MASTER ?OF ?SCIENCE ?in ?THE ?FACULTY ?OF ?GRADUATE ?AND ?POSTDOCTORAL ?STUDIES ?(Pathology ?and ?Laboratory ?Medicine) ? ? ? ?THE ?UNIVERSITY ?OF ?BRITISH ?COLUMBIA ? ?(Vancouver) ? ?October ?2013 ? ?? ?Matthew ?Allard, ?2013 ?ii ?Abstract ? ? ?Background: ? ?Familial ?hypercholesterolemia ?(FH) ?is ?a ?common ?autosomal ?dominant ?disorder ?caused ?by ?mutations ?in ?the ?low-??density ?lipoprotein ?(LDL) ?receptor, ?apolipoprotein ?B-??100 ?gene, ?or ?proprotein ?convertase ?subtilisin/kexin ?type ?9, ?resulting ?in ?very ?high ?blood ?cholesterol ?levels ?and ?premature ?cardiovascular ?disease ?(CVD). ? ? ?Hypotheses/ ?Objectives: ? ?1. FH ?patients ?who ?have ?developed ?CVD ?differ ?from ?those ?free ?of ?CVD ?by ?specific ?risk ?factors. ?2. The ?specific ?risk ?factors ?differ ?in ?FH ?patients ?who ?develop ?CVD ?early ?and ?those ?resistant ?to ?CVD ?3. These ?risk ?factors ?risk ?factors ?differ ?between ?men ?and ?women. ?4. These ?risk ?factors ?differ ?between ?ethnic ?groups. ? ? ?Methods: ?A ?retrospective ?chart ?review ?of ?patients ?in ?the ?Prevention ?Clinic ?was ?carried ?out ?to ?find ?individuals ?with ??definite? ?FH ?according ?to ?the ?Dutch ?Lipid ?Clinic ?Network ?Criteria ?(DLCNC) ?and ?to ?determine ?which ?patients ?developed ?CVD. ?Cox ?proportional ?hazard ?regression ?analysis ?was ?used ?to ?assess ?the ?association ?of ?risk ?factors ?to ?hard ?cardiovascular ?outcomes ?in ?univariate ?and ?multivariate ?analyses. ? ?Results: ? ?A ?total ?of ?446 ?patients ?were ?identified ?as ?having ??definite? ?FH ?based ?upon ?the ?DLCNC ?with ?116 ?(26%) ?patients ?having ?hard ?evidence ?of ?CVD. ?Male ?sex, ?smoking, ?family ?history ?of ?premature ?CVD, …
has type: Thesis/Dissertation
date issued: 2013-11
is shown at: 10.14288/1.0165598
language: eng
degree discipline: Pathology and Laboratory Medicine
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/45312