The effect of vitamin D supplementation during pregnancy and lactation on maternal & infant 25-hydroxyvitamin D concentration
department or school: Land and Food Systems, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Chen, Nancy Nannan
issued: 2013-08-30T15:11:27Z
issued: 2013
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: BACKGROUND: Adequate vitamin D during pregnancy and lactation is important for optimal health of mother and infant. Due to low levels of vitamin D occurring in breast milk, exclusively breastfed infants are recommended by Health Canada to be supplemented with 400 IU/day of vitamin D. A potential solution to this is maternal vitamin D supplementation during pregnancy and lactation to raise maternal, infant serum 25-hydroxyvitamin D (25OHD) and breast milk vitamin D content. OBJECTIVE: To determine the effect of three dose regimens of supplemental vitamin D (400 IU/d, 1000 IU/d and 2000 IU/d) during pregnancy and lactation on maternal and infant 25-hydroxyvitamin D concentrations at 8 weeks post-partum. METHODS: In a double-blind, randomized controlled trial healthy pregnant women (n=226) between 13-24 weeks of gestation were recruited from Vancouver, Canada and randomized to take one of three doses of supplemental vitamin D3 (400 IU/d, 1000 IU/d or 2000 IU/d) until 8 weeks postpartum. Maternal blood was collected at baseline, 36 weeks gestation, and maternal and infant blood were collected 8 weeks postpartum. RESULTS: Mean 25OHD was 66 nmol/L at baseline and 21% of participants had a 25OHD < 50 nmol/L. At 8 weeks postpartum, maternal serum 25OHD concentrations [mean (95% CI)] were highest in the 2000 IU/d [87 (83, 90) nmol/L] followed by the 1000 IU/d [78 (74,81) nmol/L] and the 400 IU/d [69 (66, 73) nmol/L] group using intent to treat analysis. Likewise, at 8 weeks serum 25OHD concentrations were highest in infants whose mothers received 2000 IU/d [75 (67, 83 nmol/L)] followed by the 1000 IU/d [52 (45, 58) nmol/L] and the 400 IU/d [45 (38,52) nmol/L]. CONCLUSION: Maternal vitamin D supplementation of 2000 IU/d during pregnancy and lactation was found to be protective against vitamin D deficiency in infants for the first two months after birth. Generally, vitamin D supplementation increased maternal and infant 25OHD concentrations in a dose response manner.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/44967
note: THE EFFECT OF VITAMIN D SUPPLEMENTATION DURING PREGNANCY AND LACTATION ON MATERNAL & INFANT 25-HYDROXYVITAMIN D CONCENTRATION Nancy Nannan Chen B.Sc., The University of British Columbia, 2009 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Human Nutrition) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) August 2013 ? Nancy Nannan Chen, 2013 ii Abstract BACKGROUND: Adequate vitamin D during pregnancy and lactation is important for optimal health of mother and infant. Due to low levels of vitamin D occurring in breast milk, exclusively breastfed infants are recommended by Health Canada to be supplemented with 400 IU/day of vitamin D. A potential solution to this is maternal vitamin D supplementation during pregnancy and lactation to raise maternal, infant serum 25-hydroxyvitamin D (25OHD) and breast milk vitamin D content. OBJECTIVE: To determine the effect of three dose regimens of supplemental vitamin D (400 IU/d, 1000 IU/d and 2000 IU/d) during pregnancy and lactation on maternal and infant 25-hydroxyvitamin D concentrations at 8 weeks post-partum. METHODS: In a double-blind, randomized controlled trial healthy pregnant women (n=226) between 13-24 weeks of gestation were recruited from Vancouver, Canada and randomized to take one of three doses of supplemental vitamin D3 (400 IU/d, 1000 IU/d or 2000 IU/d) until 8 weeks postpartum. Maternal blood was collected at baseline, 36 weeks gestation, and maternal and infant blood were collected 8 weeks postpartum. RESULTS: Mean 25OHD was 66 nmol/L at baseline and 21% of participants had a 25OHD < 50 nmol/L. At 8 weeks postpartum, maternal serum 25OHD concentrations [mean (95% CI)] were highest in the 2000 IU/d [87 (83, 90) nmol/L] followed by the 1000 IU/d [78 (74,81) nmol/L] and the 400 IU/d [69 (66, 73) nmol/L] group using intent to treat analysis. Likewise, at 8 weeks serum 25OHD concentrations were highest in infants wh…
has type: Thesis/Dissertation
date issued: 2013-11
is shown at: 10.14288/1.0074205
language: eng
degree discipline: Human Nutrition
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/44967