High-intensity exercise and safety concerns in breast cancer survivors
department or school: Education, Faculty of
department or school: Kinesiology, School of
data provider: DSpace
degree campus: UBCV
creator: Dolan, Lianne Bronagh
issued: 2013-10-12T07:00:00Z
issued: 2013
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Prescribing exercise as an adjuvant therapy for cancer survivors is becoming an acknowledged rehabilitative tool to offset the numerous biological toxicities that can develop with cancer treatments. Exercise interventions for breast cancer survivors typically prescribe low-to- moderate intensities to counteract the treatment-induced dysfunctions. These prescriptions have elicited inconsistent results. Interval training is currently being explored in many clinical populations with positive outcomes; however, the use of higher intensity exercise in the cancer population is not yet encouraged. Through four different studies, this doctoral dissertation investigated the safety of implementing higher intensity exercise protocols into breast cancer survivor rehabilitative programs during chemotherapy (N=60) and post-primary therapy (N=33). The influence of intensity on safety, aerobic capacity and anaerobic capacity was explored. Supervised exercise programs and maximal aerobic stress tests were administered on a treadmill as it was demonstrated to be the preferred mode of exercise; in spite of this, the measure of anaerobic capacity was determined to be the most reliable on a cycle ergometer. Safety issues concerning neutropenia, altered chemotherapy dose, and biomarkers associated with poor outcome, were investigated. During chemotherapy (FEC-D), 30 early-stage breast cancer patients exercised at intensities between 70- 90% V02peak, thrice weekly, for the duration of their treatment (18.5 weeks). Women were able to safely incorporate bouts of higher intensity exercise without increased hospitalization, immunosuppression, or negatively impacting their chemotherapy dose (achieved RDI was 92%, achieved RDI in the matched, usual care group was 90%). Post-primary therapy, 33 postmenopausal breast cancer survivors were randomized into 3 groups (supervised high-intensity interval training (HIT), supervised continuous moderate-intensity exercise training (CMT) and an unsupervise…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/44196
note: HIGH-INTENSITY EXERCISE AND SAFETY CONCERNS IN BREAST CANCER SURVIVORS by Lianne Bronagh Dolan B.Sc., The University of Western Ontario, 2003 M.Sc., The University of British Columbia, 2007 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in The Faculty of Graduate Studies (Kinesiology) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) April 2013 ! Lianne Bronagh Dolan, 2013 !!! ! ""! Abstract Prescribing exercise as an adjuvant therapy for cancer survivors is becoming an acknowledged rehabilitative tool to offset the numerous biological toxicities that can develop with cancer treatments. Exercise interventions for breast cancer survivors typically prescribe low-to- moderate intensities to counteract the treatment-induced dysfunctions. These prescriptions have elicited inconsistent results. Interval training is currently being explored in many clinical populations with positive outcomes; however, the use of higher intensity exercise in the cancer population is not yet encouraged. Through four different studies, this doctoral dissertation investigated the safety of implementing higher intensity exercise protocols into breast cancer survivor rehabilitative programs during chemotherapy (N=60) and post-primary therapy (N=33). The influence of intensity on safety, aerobic capacity and anaerobic capacity was explored. Supervised exercise programs and maximal aerobic stress tests were administered on a treadmill as it was demonstrated to be the preferred mode of exercise; in spite of this, the measure of anaerobic capacity was determined to be the most reliable on a cycle ergometer. Safety issues concerning neutropenia, altered chemotherapy dose, and biomarkers associated with poor outcome, were investigated. During chemotherapy (FEC-D), 30 early-stage breast cancer patients exercised at intensities between 70- 90% V02peak, thrice weekly, for the duration of their treatment (18.5 weeks). Women were able to safely incorporate…
has type: Thesis/Dissertation
date issued: 2013-05
is shown at: 10.14288/1.0073770
language: eng
degree discipline: Kinesiology
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivs 3.0 Unported
rights URI: http://creativecommons.org/licenses/by-nc-nd/3.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/44196