The effect of three dosages of supplemental vitamin D (400, 1000 and 2000 IU) on maternal and newborn 25-hydroxyvitamin D concentrations
department or school: Land and Food Systems, Faculty of
data provider: DSpace
degree campus: UBCV
creator: March, Kaitlin
issued: 2012-08-27T14:01:38Z
issued: 2012
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: BACKGROUND: Attaining adequate vitamin D throughout pregnancy is important for maternal and infant health. Current Canadian guidelines for vitamin D intake vary; the Recommended Dietary Allowance (RDA) set by Health Canada is 600IU/d whereas the Canadian Pediatric Society recommends 2000IU/d. At present, there is a lack of evidence as to the most appropriate intake. OBJECTIVE: To determine the effect of each of three dosages of supplemental vitamin D (400, 1000 and 2000IU) throughout pregnancy on the percentage of women achieving sufficient serum 25-hydroxyvitamin D (25OHD) defined as > 50 nmol/L and the maternal and newborn 25OHD concentrations in response to each supplementation dose. METHODS: In a randomized, double-blind, controlled trial pregnant women (n=110) were randomized to one of three doses of supplemental vitamin D³ (400, 1000 or 2000 IU) at 13-22 weeks (baseline). Participants attended a study visit at 36 weeks and infant cord blood was collected at delivery. Blood was collected for analysis for serum 25OHD at baseline and 36 weeks gestation. RESULTS: At baseline 18.2% of participants were classified as vitamin D insufficient (serum 25OHD < 50 nmol/L) with 10.9% vitamin D insufficient at 36 weeks. There were no significant differences among treatment groups in the percentage of women classified as vitamin D insufficient at 36 weeks gestation [400IU: 11%, 1000IU: 18.4%, 2000IU: 5.6%, p=0.227] or in serum 25OHD concentrations [400IU: 70.4±19.5 nmol/L, 1000IU: 76.5±25.7 nmol/L, 2000IU 80.1±20.3 nmol/L, p=0.178]. The change in serum 25OHD concentrations from baseline to 36 weeks was significantly greater in the 1000IU and 2000IU group versus the 400IU group [400IU: -0.08±15.5 nmol/L, 1000IU: 10.5±20.8 nmol/L, 2000IU:12.4±13.7 nmol/L, p=0.005] Newborn serum 25OHD concentrations did not differ across treatments [400IU: 72.2±21.4, 1000IU: 65.5±22.6, 2000IU: 91.5±19.8, p=0.111]. CONCLUSION: There were no significant differences among three dosages of supplemen…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/43063
note: THE EFFECT OF THREE DOSAGES OF SUPPLEMENTAL VITAMIN D (400, 1000 AND 2000 IU) ON MATERNAL AND NEWBORN 25-HYDROXYVITAMIN D CONCENTRATIONS by Kaitlin March B.Sc., Queen’s University, 2009 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE STUDIES (Human Nutrition) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) August 2012 © Kaitlin March, 2012 i Abstract BACKGROUND: Attaining adequate vitamin D throughout pregnancy is important for maternal and infant health. Current Canadian guidelines for vitamin D intake vary; the Recommended Dietary Allowance (RDA) set by Health Canada is 600IU/d whereas the Canadian Pediatric Society recommends 2000IU/d. At present, there is a lack of evidence as to the most appropriate intake. OBJECTIVE: To determine the effect of each of three dosages of supplemental vitamin D (400, 1000 and 2000IU) throughout pregnancy on the percentage of women achieving sufficient serum 25-hydroxyvitamin D (25OHD) defined as > 50 nmol/L and the maternal and newborn 25OHD concentrations in response to each supplementation dose. METHODS: In a randomized, double-blind, controlled trial pregnant women (n=110) were randomized to one of three doses of supplemental vitamin D3 (400, 1000 or 2000 IU) at 13- 22 weeks (baseline). Participants attended a study visit at 36 weeks and infant cord blood was collected at delivery. Blood was collected for analysis for serum 25OHD at baseline and 36 weeks gestation. RESULTS: At baseline 18.2% of participants were classified as vitamin D insufficient (serum 25OHD < 50 nmol/L) with 10.9% vitamin D insufficient at 36 weeks. There were no significant differences among treatment groups in the percentage of women classified as vitamin D insufficient at 36 weeks gestation [400IU: 11%, 1000IU: 18.4%, 2000IU: 5.6%, p=0.227] or in serum 25OHD concentrations [400IU: 70.4±19.5 nmol/L, 1000IU: 76.5±25.7 nmol/L, 2000IU 80.1±20.3 nmol/L, p=0.178]. The change in serum 2…
has type: Thesis/Dissertation
date issued: 2012-11
is shown at: 10.14288/1.0073064
language: eng
degree discipline: Human Nutrition
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivs 3.0 Unported
rights URI: http://creativecommons.org/licenses/by-nc-nd/3.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/43063