Immunomodulatory and wound-healing effects of the host defence peptide LL-37 and related innate defence regulators
department or school: Science, Faculty of
department or school: Microbiology and Immunology, Department of
data provider: DSpace
degree campus: UBCV
creator: Nicholls, Erin Frances
issued: 2012-03-14T16:59:32Z
issued: 2012
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: LL-37, the only known human cathelicidin peptide, possesses a variety of immunomodulatory properties that extend its role in host defence far beyond its original classification as an antimicrobial peptide. Recently, work has been underway to elucidate signalling pathways initiated by LL-37, with the aim of further understanding this peptide’s role in the immune system. The aim of this study was to further uncover the role of transcription factors during the responses of immune cells to LL-37 and related innate defence regulator peptides. Secondary aims were to investigate potential wound-healing properties of these peptides and to compare host defence peptides with chemokines in terms of immunomodulatory function. Here, I demonstrated involvement of AP-1 in LL-37-induced wound healing. I also showed a functional overlap between chemokine CXCL9/MIG and host defence peptide LL-37 and demonstrated similarities between LL-37 and the antibiotic azithromycin.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/41389
note: IMMUNOMODULATORY AND WOUND-HEALING EFFECTS OF THE HOST DEFENCE PEPTIDE LL-37 AND RELATED INNATE DEFENCE REGULATORS by Erin Frances Nicholls B.Sc. Microbiology and Immunology, The University of British Columbia, 2006 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE STUDIES (Microbiology and Immunology) The University of British Columbia (Vancouver) March 2012 © Erin Frances Nicholls, 2012 ii Abstract LL-37, the only known human cathelicidin peptide, possesses a variety of immunomodulatory properties that extend its role in host defence far beyond its original classification as an antimicrobial peptide. Recently, work has been underway to elucidate signalling pathways initiated by LL-37, with the aim of further understanding this peptide’s role in the immune system. The aim of this study was to further uncover the role of transcription factors during the responses of immune cells to LL-37 and related innate defence regulator peptides. Secondary aims were to investigate potential wound-healing properties of these peptides and to compare host defence peptides with chemokines in terms of immunomodulatory function. Here, I demonstrated involvement of AP-1 in LL-37-induced wound healing. I also showed a functional overlap between chemokine CXCL9/MIG and host defence peptide LL-37 and demonstrated similarities between LL-37 and the antibiotic azithromycin. iii Preface This thesis contains parts of two published manuscripts. Copyright permission was granted for both. The manuscript “Nicholls, E.F., L. Madera and R. E. W. Hancock. 2010. Immunomodulators as adjuvants for vaccines and antimicrobial therapy. Ann. NY Acad. Sci. 1213:46-61." appears as part of the Introduction. The manuscript "Gong, J.-H.*, E.F. Nicholls*, M.R. Elliott, K.L. Brown, K. Hokamp, F.M. Roche, C.Y Cheung, R. Falsafi, F.S. Brinkman, D.M.E. Bowdish, and R.E.W. Hancock. 2010. G-protein-coupled receptor independent, immunomodulatory…
has type: Thesis/Dissertation
date issued: 2012-05
is shown at: 10.14288/1.0072629
language: eng
degree discipline: Microbiology and Immunology
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/41389