http://dx.doi.org/10.14288/1.0406194
department or school: Medicine, Faculty of
department or school: Population and Public Health (SPPH), School of
data provider: DSpace
degree campus: UBCV
creator: Xie, Max Wenheng
issued: 2022-01-06T21:27:23Z
issued: 2021
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Background Opioid overdoses, particularly from fentanyl are a growing public health crisis throughout North America. Canada recorded a staggering 21,056 opioid-related overdose deaths between 2016-2020. In the same period, compared to other provinces, British Columbia (BC) has constantly had the highest annual opioid overdose death rate. Individuals that experience fatal overdose are eligible to become organ donors. This study characterizes overdosed deceased donors (ODDs) and examines safety of outcomes for recipients of ODD compared to non-ODD organ transplantation in BC. Methods Data on deceased donors and their recipients were extracted from the Patient Records and Outcome Management Information System database from 2013-2019. Chart review was undertaken for each donor to determine whether drug overdose was the cause of death. We analyzed recipient outcomes for double-lung, heart, liver, and kidney transplantations. The Kaplan-Meier method was used to estimate unadjusted 5-year recipient outcomes. Donor, recipient, and transplant characteristics were balanced using inverse probability of treatment weighting. Weighted multivariable Cox proportional hazards regression models were used to estimate 3-year recipient outcomes comparing recipients of ODD and non-ODD transplantation. Results Between 2013-2019, 605 local deceased donors (457 non-ODDs and 148 ODDs) donated a solid organ to 1,795 transplant recipients resulting in 1,857 transplantations in BC. Compared to non-ODDs, ODDs were more likely to be young white males with fewer comorbidities such as hypertension and diabetes but have higher terminal creatinine and a greater prevalence of HCV. The probability of remaining event free at 5-year post-transplant for ODD double-lung (80%), heart (87%), liver (84%), and kidney (97%) recipients were high. ODD status did not affect recipient transplant survival in double-lung (hazard ratio (HR): 1.06, 95% confidence interval (CI): 0.41 â 2.70, p = 0.908) and liver (HR: 0.…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/80567
note: IMPACT OF THE OPIOID CRISIS ON TRANSPLANTATION IN BRITISH COLUMBIA, CANADA; EVALUATING ORGAN UTILIZATION AND TRANSPLANT OUTCOMES FOR RECIPIENTS OF DECEASED DONOR ORGANS FROM INDIVIDUALS WHO DIED FROM OVERDOSE by Max Wenheng Xie B.Sc., The University of British Columbia, 2018 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Population and Public Health) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) December 2021 © Max Wenheng Xie, 2021 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, a thesis entitled: âImpact of the opioid crisis on transplantation in British Columbia, Canada; evaluating organ utilization and transplant outcomes for recipients of deceased donor organs from individuals who died from overdoseâ submitted by Max Wenheng Xie in partial fulfillment of the requirements for the degree of Master of Science in Population and Public Health Examining Committee: Dr. Caren Rose, Assistant Professor, School of Population and Public Health, UBC Supervisor Dr. Joel Singer, Professor, School of Population and Public Health, UBC Supervisory Committee Member Dr. Sean P. Keenan, Clinical Associate Professor, Department of Medicine, UBC Supervisory Committee Member Dr. Amee Manges, Professor, School of Population and Public Health, UBC Additional Examiner iii Abstract Background Opioid overdoses, particularly from fentanyl are a growing public health crisis throughout North America. Canada recorded a staggering 21,056 opioid-related overdose deaths between 2016-2020. In the same period, compared to other provinces, British Columbia (BC) has constantly had the highest annual opioid overdose death rate. Individuals that experience fatal overdose are eligible to become organ donors. This study characterizes overdosed deceased donors (ODDs) and examines safety of outcomes for recipie…
has type: Thesis/Dissertation
date issued: 2022-05
is shown at: 10.14288/1.0406194
language: eng
degree discipline: Population and Public Health
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Rose, Caren Lee
title: Impact of the opioid crisis on transplantation in British Columbia, Canada; evaluating organ utilization and transplant outcomes for recipients of deceased donor organs from individuals who died from overdose
type: Text
identifier URI: http://hdl.handle.net/2429/80567