Biomechanical properties of paraspinal muscles and their influence on spinal loading : an experimental and computational investigation
department or school: Applied Science, Faculty of
department or school: Mechanical Engineering, Department of
data provider: DSpace
degree campus: UBCV
creator: Malakoutian, Masoud
issued: 2021-06-02T17:16:01Z
issued: 2021
related degree: Doctor of Philosophy - PhD
degree grantor: University of British Columbia
description: Adult spinal deformity (ASD) is prevalent among ~30% of the population above 65 years old. While decreased back extensor strength in the form of muscle weakness/dysfunction is well-documented for these patients, it is unclear what muscle properties lead to such decreased strength. The overall goal of this research project was to investigate if biomechanical properties of the paraspinal muscles are different in ASD patients; and whether those differences could influence spinal loading and be associated with the initiation/progression of ASD. To achieve this goal, four studies were conducted. The first study examined the effect of spinal level on elastic modulus, slack sarcomere length, and collagen deposition in paraspinal muscles of 13 rats revealing independence of those properties on the spinal level. In the second study, the influence of the size of single muscle fibers and fiber bundles on elastic modulus was investigated for both rodents and humans. Smaller fibers and fiber bundles manifested larger elastic moduli, highlighting the necessity of aiming for consistent bundle sizes for passive property measurement. For the third study, ethical and technical requirements for intraoperative human muscle biopsy acquisition were addressed and paraspinal muscle biopsies were collected from nine ASD patients. Although patient-recruitment halted because of COVID-19 and thus the small number of patients did not allow performing a statistical comparison between the patients, thought-provoking observations were made. In situ- and slack sarcomere lengths had large variations; several fiber bundles exhibited substantially high stiffnesses, and histopathological analysis unveiled a variety of extracellular and intracellular case-specific abnormalities. The variations observed for the biomechanical properties were input to an enhanced musculoskeletal model of the thoracolumbar spine, which predicted increases in the intradiscal pressures by several orders of magnitudes in some …
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/78513
note: BIOMECHANICAL PROPERTIES OF PARASPINAL MUSCLES AND THEIR INFLUENCE ON SPINAL LOADING AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION by Masoud Malakoutian B.A.Sc., The University of Tehran, 2011 M.A.Sc., The University of British Columbia, 2014 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in The Faculty of Graduate and Postdoctoral Studies (Mechanical Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) May 2021 © Masoud Malakoutian, 2021 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the dissertation entitled: Biomechanical Properties of Paraspinal Muscles and Their Influence on Spinal Loading: An Experimental and Computational Investigation submitted by Masoud Malakoutian in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Mechanical Engineering Examining Committee: Dr. Thomas R. Oxland, Professor, Departments of Orthopaedics and Mechanical Engineering, UBC Supervisor Dr. Sidney Fels, Professor, Department of Electrical and Computer Engineering , UBC Supervisory Committee Member Dr. Stephen H. M. Brown, Associate Professor, Department of Human Health and Nutritional Sciences, University of Guelph Supervisory Committee Member Anasavarapu Srikantha Phani, Associate Professor, Department of Mechanical Engineering, UBC University Examiner Jean-Sébastien Blouin, Professor, School of Kinesiology, UBC University Examiner Additional Supervisory Committee Members: Dr. David Wilson, Professor, Departments of Orthopaedics and Mechanical Engineering, UBC Supervisory Committee Member iii Abstract Adult spinal deformity (ASD) is prevalent among ~30% of the population above 65 years old. While decreased back extensor strength in the form of muscle weakness/dysfunction is well-documented for these patients, it is unclear what muscle properties lead to such decreased strength. The overall goal…
has type: Thesis/Dissertation
date issued: 2021-11
is shown at: 10.14288/1.0398230
language: eng
degree discipline: Mechanical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Oxland, Thomas R.
type: Text
identifier URI: http://hdl.handle.net/2429/78513