New concepts in transcatheter mitral valve replacement
department or school: Applied Science, Faculty of
department or school: Mechanical Engineering, Department of
data provider: DSpace
degree campus: UBCO
creator: Goode, Dylan James Ellingham
issued: 2020-04-23T21:07:58Z
issued: 2020
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: The most prevalent form of moderate to severe valve disease in developed countries is mitral regurgitation (MR), which affects ~10% of people older than 75 years of age. Roughly half of patients with severe symptomatic MR are not referred for surgery due to risks of age, comorbid factors and frailty. With these outcomes, a minimally invasive procedural option is required. The emergence of transcatheter aortic valve replacement (TAVR) has segued the development of transcatheter mitral valve (MV) repair devices. Transcatheter mitral valve repair has become a well-established alternative for patients with severe primary and secondary mitral regurgitation (MR) and with a perceived surgical risk. Transcatheter mitral valve replacement (TMVR) could become a more complete form of reduction of severe MR compared to MV repair devices, albeit with significant engineering challenges and all the risks associated with a bioprosthetic heart valve. The development of TMVR devices has become prominent while companies race to become the first commercially available system. Preclinical and clinical trials have shown promising results, showcasing the feasibility of total valve replacement utilizing transcatheter procedure techniques. This thesis is focused on evaluating the feasibility of novel TMVR devices. It is comprised of three major components: design and fabrication of MV leaflets; design of TMVR stents; as well as design and fabrication of a miniaturized heart simulator. Additionally, an extensive literature review of relevant clinical and preclinical designs to fully map out the TMVR landscape. A novel bileaflet valve was designed for implantation into a TMVR stent. The kinematics of the leaflet motion were evaluated, resulting in a positive feasibility assessment of the design with room for further iterations. An additional bileaflet valve was designed to perform a computational model evaluating wrinkle-induced tearing of prosthetic MVs. A trileaflet valve was designed to ev…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/74136
note: New Concepts in Transcatheter Mitral Valve Replacement by Dylan James Ellingham Goode B.ASc, The University of British Columbia, 2018 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF APPLIED SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Mechanical Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Okanagan) April 2020 © Dylan James Ellingham Goode, 2020 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, a thesis/dissertation entitled: New Concepts in Transcatheter Mitral Valve Replacement submitted by Dylan James Ellingham Goode in partial fulfillment of the requirements for the degree of Master of Applied Science in Mechanical Engineering Examining Committee: Dr. Hadi Mohammadi, Faculty of Applied Science Supervisor Dr. Ray Taheri, Faculty of Applied Science Supervisory Committee Member Dr. Zheng Liu, Faculty of Applied Science Supervisory Committee Member Dr. Ian Foulds, Faculty of Applied Science University Examiner iii Abstract The most prevalent form of moderate to severe valve disease in developed countries is mitral regurgitation (MR), which affects ~10% of people older than 75 years of age. Roughly half of patients with severe symptomatic MR are not referred for surgery due to risks of age, comorbid factors and frailty. With these outcomes, a minimally invasive procedural option is required. The emergence of transcatheter aortic valve replacement (TAVR) has segued the development of transcatheter mitral valve (MV) repair devices. Transcatheter mitral valve repair has become a well-established alternative for patients with severe primary and secondary mitral regurgitation (MR) and with a perceived surgical risk. Transcatheter mitral valve replacement (TMVR) could become a more complete form of reduction of severe MR compared to MV repair devices, albeit with significant engineering challenges and all the risks associa…
has type: Thesis/Dissertation
date issued: 2020-05
is shown at: 10.14288/1.0389945
language: eng
degree discipline: Mechanical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/74136