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Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting Ma, Wei Jen; Wang, Changqing; Kothandapani, Jagatheeswaran; Luzentales-Simpson, Matthew; Menzies, Susan; Bescucci, Danisa; Lange, Máximo; Fraser, Alexander; Gusse, Jenny; House, Kathaleen; Moote, Paul; Xing, Xiaohui; Grondin, Julie; Hui, Benjamin Wei Qiang; Clarke, Sandra; Shelton, Tara; Haskey, Natasha; Gibson, Deanna; Martens, Eric; Abbott, Wade; Inglis, G. Douglas; Sly, Laura; Brumer, Harry
Description
<b>Abstract</b><br/>
The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled the release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease. Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy.</p>
Item Metadata
| Title |
Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting
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| Creator |
Ma, Wei Jen; Wang, Changqing; Kothandapani, Jagatheeswaran; Luzentales-Simpson, Matthew; Menzies, Susan; Bescucci, Danisa; Lange, Máximo; Fraser, Alexander; Gusse, Jenny; House, Kathaleen; Moote, Paul; Xing, Xiaohui; Grondin, Julie; Hui, Benjamin Wei Qiang; Clarke, Sandra; Shelton, Tara; Haskey, Natasha; Gibson, Deanna; Martens, Eric; Abbott, Wade; Inglis, G. Douglas; Sly, Laura; Brumer, Harry
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| Date Issued |
2025-03-13
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| Description |
<b>Abstract</b><br/>
The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled the release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease. Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy.</p> |
| Subject |
Other; Chemistry; Biochemistry; Microbiome; Inflammatory bowel disease; Mouse models; Immunology; Drug delivery; Steroids; Salicylates; Bioinformatics; Enzymology; Carbohydrates; Polysaccharides; Microbiology; NMR spectroscopy; Pharmacokinetics; Enzyme kinetics; Metagenomics; Gut bacteria; Histology; gross pathology; Cytokines
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| Type | |
| Notes |
Dryad version number: 5</p> Version status: submitted</p> Dryad curation status: Published</p> Sharing link: http://datadryad.org/dataset/doi:10.5061/dryad.np5hqc04q</p> Storage size: 899833585</p> Visibility: public</p> |
| Date Available |
2025-03-07
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| Provider |
University of British Columbia Library
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| License |
CC0 1.0
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| DOI |
10.14288/1.0448204
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| URI | |
| Publisher DOI | |
| Grant Funding Agency |
Innovation, Science and Economic Development Canada; Canadian Institutes of Health Research; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council; Natural Sciences and Engineering Research Council; Natural Sciences and Engineering Research Council; Natural Sciences and Engineering Research Council; Agriculture and Agri-Food Canada; Michael Smith Health Research BC; Alberta Innovates; Crohn's and Colitis Canada; Crohn's and Colitis Canada; Crohn's and Colitis Canada; Michael Smith Health Research BC
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| Rights URI | |
| Aggregated Source Repository |
Dataverse
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Licence
CC0 1.0