Data from: Overdominance interacts with linkage to determine the rate of adaptation to a new optimum

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Data from: Overdominance interacts with linkage to determine the rate of adaptation to a new optimum Draghi, Jeremy; Whitlock, Michael C.

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Abstract
Overdominance, or a fitness advantage of a heterozygote over both homozygotes, can occur commonly with adaptation to a new optimum phenotype. We model how such overdominant polymorphisms can reduce the evolvability of diploid populations, uncovering a novel form of epistatic constraint on adaptation. The fitness load caused by overdominant polymorphisms can most readily be ameliorated by evolution at tightly linked loci; therefore traits controlled by multiple loosely linked loci are predicted to be strongly constrained. The degree of constraint is also sensitive to the shape of the relationship between phenotype and fitness, and the constraint caused by overdominance can be strong enough to overcome the effects of clonal interference on the rate of adaptation for a trait. These results point to novel influences on evolvability that are specific to diploids and interact with genetic architecture, and they predict a source of stochastic variability in eukaryotic evolution experiments or cases of rapid evolution in nature.
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Title	Data from: Overdominance interacts with linkage to determine the rate of adaptation to a new optimum
Creator	Draghi, Jeremy; Whitlock, Michael C.
Date Issued	2021-05-19
Description	Abstract Overdominance, or a fitness advantage of a heterozygote over both homozygotes, can occur commonly with adaptation to a new optimum phenotype. We model how such overdominant polymorphisms can reduce the evolvability of diploid populations, uncovering a novel form of epistatic constraint on adaptation. The fitness load caused by overdominant polymorphisms can most readily be ameliorated by evolution at tightly linked loci; therefore traits controlled by multiple loosely linked loci are predicted to be strongly constrained. The degree of constraint is also sensitive to the shape of the relationship between phenotype and fitness, and the constraint caused by overdominance can be strong enough to overcome the effects of clonal interference on the rate of adaptation for a trait. These results point to novel influences on evolvability that are specific to diploids and interact with genetic architecture, and they predict a source of stochastic variability in eukaryotic evolution experiments or cases of rapid evolution in nature.; Usage notes Code and Analyses
Subject	Other; Theory; Experimental evolution; population genetics
Type	Dataset
Notes	Dryad version number: 1 Version status: submitted Dryad curation status: Published Sharing link: https://datadryad.org/stash/share/eeiDhk2xYxVSfRu9O6a4lHIWMXyaJ-kEOK_ojbGKCrY</p> Storage size: 83846750 Visibility: public
Date Available	2020-06-30
Provider	University of British Columbia Library
License	CC0 1.0
DOI	10.14288/1.0397916
URI	https://doi.org/10.5683/SP2/SRK9OS
Publisher DOI	https://doi.org/10.5683/SP2/SRK9OS; https://doi.org/10.5061/dryad.6f2j8
Rights URI	http://creativecommons.org/publicdomain/zero/1.0
Aggregated Source Repository	Dataverse

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