Open Collections

UBC Research Data

Data from: Naked mole rats exhibit metabolic but not ventilatory plasticity following chronic sustained hypoxia Chung, Danielle; Dzal, Yvonne; Seow, Allison; Milsom, William; Pamenter, Matthew; Dzal, Yvonne A.; Milsom, William K.; Pamenter, Matthew E.

Description

<b>Abstract</b><br/>Naked mole rats are among the most hypoxia-tolerant mammals identified and live in chronic hypoxia throughout their lives. The mechanisms underlying this tolerance, however, are poorly understood. Most vertebrates hyperventilate in acute hypoxia and exhibit an enhanced hyperventilation following acclimatization to chronic sustained hypoxia (CSH). Conversely, naked mole rats do not hyperventilate in acute hypoxia and their response to CSH has not been examined. In this study we explored mechanisms of plasticity in the control of the hypoxic ventilatory response (HVR) and hypoxic metabolic response (HMR) of freely behaving naked mole rats following 8-10 days of chronic sustained normoxia (CSN) or CSH. Specifically, we investigated the role of the major inhibitory neurotransmitter γ-amino butyric acid (GABA) in mediating these responses. Our study yielded three important findings. First, naked mole rats did not exhibit ventilatory plasticity following CSH, which is unique among adult animals studied to date. Second, GABA receptor (GABAR) antagonism altered breathing patterns in CSN and CSH animals and modulated the acute HVR in CSN animals. Third, naked mole rats exhibited GABAR-dependent metabolic plasticity following long-term hypoxia, such that the basal metabolic rate was ~25% higher in normoxic CSH animals than CSN animals, and GABAR antagonists modulated this increase.; <b>Usage notes</b><br /><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Raw data for Proceedings</h4><div class="o-metadata__file-description">This file contains raw LabChart files documenting changes ventilation and metabolism during an acute hypoxic exposure in naked mole rats acclimated to 8-10 day of either chronic sustained normoxia or chronic sustained hypoxia</div><div class="o-metadata__file-name"></div></div>

Item Metadata

Title	Data from: Naked mole rats exhibit metabolic but not ventilatory plasticity following chronic sustained hypoxia
Creator	Chung, Danielle; Dzal, Yvonne; Seow, Allison; Milsom, William; Pamenter, Matthew; Dzal, Yvonne A.; Milsom, William K.; Pamenter, Matthew E.
Date Issued	2021-05-19
Description	<b>Abstract</b><br/>Naked mole rats are among the most hypoxia-tolerant mammals identified and live in chronic hypoxia throughout their lives. The mechanisms underlying this tolerance, however, are poorly understood. Most vertebrates hyperventilate in acute hypoxia and exhibit an enhanced hyperventilation following acclimatization to chronic sustained hypoxia (CSH). Conversely, naked mole rats do not hyperventilate in acute hypoxia and their response to CSH has not been examined. In this study we explored mechanisms of plasticity in the control of the hypoxic ventilatory response (HVR) and hypoxic metabolic response (HMR) of freely behaving naked mole rats following 8-10 days of chronic sustained normoxia (CSN) or CSH. Specifically, we investigated the role of the major inhibitory neurotransmitter γ-amino butyric acid (GABA) in mediating these responses. Our study yielded three important findings. First, naked mole rats did not exhibit ventilatory plasticity following CSH, which is unique among adult animals studied to date. Second, GABA receptor (GABAR) antagonism altered breathing patterns in CSN and CSH animals and modulated the acute HVR in CSN animals. Third, naked mole rats exhibited GABAR-dependent metabolic plasticity following long-term hypoxia, such that the basal metabolic rate was ~25% higher in normoxic CSH animals than CSN animals, and GABAR antagonists modulated this increase.; <b>Usage notes</b><br /><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Raw data for Proceedings</h4><div class="o-metadata__file-description">This file contains raw LabChart files documenting changes ventilation and metabolism during an acute hypoxic exposure in naked mole rats acclimated to 8-10 day of either chronic sustained normoxia or chronic sustained hypoxia</div><div class="o-metadata__file-name"></div></div>
Subject	Other; hypoxic metabolic response; ventilatory acclimatization to hypoxia; heterocephalus glaber; plethysmography; hypoxic ventilatory response
Type	Dataset
Notes	Dryad version number: 1</p> Version status: submitted</p> Dryad curation status: Published</p> Sharing link: https://datadryad.org/stash/share/GSwX6AMMqVcdXT6LsvrAOGuNHL5aUmWCq2w8qH8FnN4</p> Storage size: 509212807</p> Visibility: public</p>
Date Available	2020-06-24
Provider	University of British Columbia Library
License	This dataset is made available under a Creative Commons CC0 license with the following additional/modified terms and conditions: CC0 Waiver
DOI	10.14288/1.0397717
URI	https://doi.org/10.5683/SP2/HHWI9N
Publisher DOI	https://doi.org/10.5683/SP2/HHWI9N; https://doi.org/10.5061/dryad.sq227
Rights URI	https://creativecommons.org/publicdomain/zero/1.0/
Aggregated Source Repository	Dataverse

Item Media

Item Citations and Data

Licence

This dataset is made available under a Creative Commons CC0 license with the following additional/modified terms and conditions: CC0 Waiver