Open Collections

Leathlobhair, Máire Ní; Perri, Angela R.; Irving-Pease, Evan K.; Witt, Kelsey E.; Linderholm, Anna; Haile, James; Lebrasseur, Ophelie; Ameen, Carly; Blick, Jeffrey; Boyko, Adam R.; Brace, Selina; Nunes Cortes, Yahaira; Crockford, Susan J.; Devault, Alison; Dimopoulos, Evangelos A.; Eldridge, Morley; Enk, Jacob; Gopalakrishnan, Shyam; Gori, Kevin; Grimes, Vaughan; Guiry, Eric; Hansen, Anders J.; Hulme-Beaman, Ardern; Johnson, John; Kitchen, Andrew; Kasparov, Aleksei K.; Kwon, Young-Mi; Nikolskiy, Pavel A.; Peraza Lope, Carlos; Manin, Aurélie; Martin, Terrance; Meyer, Michael; Noack Myers, Kelsey; Omura, Mark; Rouillard, Jean-Marie; Pavlova, Elena Y.; Sciulli, Paul; Mikkel-Holger, Sinding S.; Strakova, Andrea; Ivanova, Varvara V.; Widga, Christopher; Willerslev, Eske; Pitulko, Vladimir V.; Barnes, Ian; Gilbert, M. Thomas P.; Dobney, Keith M.; Malhi, Ripan S.; Murchison, Elizabeth P.; Larson, Greger; Frantz, Laurent A. F.

<b>Abstract</b><br/>Dogs were present in the Americas prior to the arrival of European colonists, but the origin and fate of these pre-contact dogs are largely unknown. We sequenced 71 mitochondrial and seven nuclear genomes from ancient North American and Siberian dogs spanning ~9,000 years. Our analysis indicates that American dogs were not domesticated from North American wolves. Instead, American dogs form a monophyletic lineage that likely originated in Siberia and dispersed into the Americas alongside people. After the arrival of Europeans, native American dogs almost completely disappeared, leaving a minimal genetic legacy in modern dog populations. Remarkably, the closest detectable extant lineage to pre-contact American dogs is the canine transmissible venereal tumor, a contagious cancer clone derived from an individual dog that lived up to 8,000 years ago.; <b>Usage notes</b><br /><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Mitochondrial DNA FASTA file</h4><div class="o-metadata__file-description">FASTA file containing 1166 dog mtDNA genomes used in this study</div><div class="o-metadata__file-name">full_mtDNA_alignment.fasta</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">NEXUS tree</h4><div class="o-metadata__file-description">Maximum likelihood tree (RAxML) of 1166 dogs mtDNA genomes used in this study</div><div class="o-metadata__file-name">full_mtDNA_alignment.tre</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Excel sheet</h4><div class="o-metadata__file-description">Publication source of the 1166 mtDNA genomes used in this study</div><div class="o-metadata__file-name">full_mtDNA_alignment.xlsx</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Plink (bed) file</h4><div class="o-metadata__file-description">Contains genotype for dogs 54 dogs</div><div class="o-metadata__file-name">full_data.bed</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Plink file (bim)</h4><div class="o-metadata__file-description">Contains genotype for 54 dogs</div><div class="o-metadata__file-name">full_data.bim</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Plink file (fam)</h4><div class="o-metadata__file-description">Contains genotype for 54 dogs</div><div class="o-metadata__file-name">full_data.fam</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">NJ tree in Figure 2b</h4><div class="o-metadata__file-description">NJ tree in Figure 2b (see Table S2 for more info)</div><div class="o-metadata__file-name">Figure_b.tre</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">Nexus file</h4><div class="o-metadata__file-description">Nexus file used for producing Figure S12 (MKV model in MrBayes)</div><div class="o-metadata__file-name">Binary_char_MKV.nex</br></div></div><div class="o-metadata__file-usage-entry"><h4 class="o-heading__level3-file-title">NEXUS tree</h4><div class="o-metadata__file-description">Bayesian tree in Figure S12 (see Table S2 for more info)</div><div class="o-metadata__file-name">Figure_S12.tre</br></div></div>

United Kingdom

Dryad version number: 1</p>

Version status: submitted</p>

Dryad curation status: Published</p>

Sharing link: https://datadryad.org/stash/share/zrwzgCscLZcxNYNjilPA1tHuWTfUMkUZXmMpSDzv83k</p>

Storage size: 121385898</p>

Visibility: public</p>

University of British Columbia Library

10.14288/1.0397683

https://doi.org/10.5683/SP2/FFOWXI; https://doi.org/10.5061/dryad.s1k47j4

Dataverse