UBC Research Data

Data from: Mutational effects depend on ploidy level: all else is not equal Gerstein, Aleeza C.


Ploidy is predicted to influence adaptation directly, yet whether single mutations behave the same in different ploidy backgrounds has not been well studied. It has often been assumed theoretically that aside from dominance, selective parameters do not differ between cells of varying ploidy. Using the budding yeast Saccharomyces cerevisiae, I compared the effect size of 20 adaptive mutations in haploids and homozygous diploids and found, surprisingly, that the same mutations often had a much larger effect in haploids than homozygous diploids. This empirical result demonstrates that it cannot be assumed that mutations will have the same effect in haploids and homozygous diploids.; Usage notes
Tolerance parameter estimates from MLcombined_A_AA_MLc.csv
BMN parameters for graphingParameters for data points (colours, position, pch etc.) from Gerstein et al. (Genetics, 2012) dataset.1207NBMnys_param.csv
Tolerance log-likelihood results from ML modelsResults from ML models for the three tolerance parameters (IC50, a50, m).NysIC50_A_AA_modelsig.csv
R code to produce Figure1 (Tolerance data)1209 Figure1.R
R code to produce Figure2 (Bioscreen data)R code for Figure 2. Includes statistical analysis for the bioscreen data.1207 Figure2_GR.R
Bioscreen dataGrowth rate data required to produce Figure 2.A_AA_rawdata.csv

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