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Type 2 Innate Lymphocytes are Crucial for Anti-tumour Immunity and Their Adoptive Transfer is an Effective Immunotherapy Against Cancer Saranchova, Iryna; Han, Jeffrey

Description

Type 2 innate lymphoid cells (ILC2) potentiate adaptive immune responses however whether they have a role in mediating cancer immunity has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and higher frequency of circulating tumour cells (CTCs) and metastasis to distal organs. Our data supports the conclusions that tumour-infiltrating ILC2s help mediate tumour immune-surveillance by promoting adaptive T cells responses and that ILC2s play a hitherto undescribed role in controlling metastasis. Furthermore, we demonstrate that adoptive transfer of ILC2s mediates a dramatic regression in cancer growth. Therefore, the adoptive transfer of ILC2s provides a new immunotherapeutic approach with the potential to aid in the eradication of cancers.

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Title	Type 2 Innate Lymphocytes are Crucial for Anti-tumour Immunity and Their Adoptive Transfer is an Effective Immunotherapy Against Cancer
Creator	Saranchova, Iryna; Han, Jeffrey
Contributor	Cuthill, Melissa
Date Issued	2019-03-05
Description	Type 2 innate lymphoid cells (ILC2) potentiate adaptive immune responses however whether they have a role in mediating cancer immunity has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and higher frequency of circulating tumour cells (CTCs) and metastasis to distal organs. Our data supports the conclusions that tumour-infiltrating ILC2s help mediate tumour immune-surveillance by promoting adaptive T cells responses and that ILC2s play a hitherto undescribed role in controlling metastasis. Furthermore, we demonstrate that adoptive transfer of ILC2s mediates a dramatic regression in cancer growth. Therefore, the adoptive transfer of ILC2s provides a new immunotherapeutic approach with the potential to aid in the eradication of cancers.
Subject	Medicine, Health and Life Sciences; Type 2 Innate Lymphocyte,; ILC2; Anti-tumour Immunity; Metastasis; Adoptive Transfer
Type	Dataset
Notes	http://hdl.handle.net/11272/10468
Date Available	2019-03-05
Provider	University of British Columbia Library
License	CC-BY 4.0
DOI	10.14288/1.0343408
URI	https://doi.org/10.5683/SP2/09Y9IJ
Publisher DOI	https://doi.org/10.5683/SP2/09Y9IJ
Rights URI	http://creativecommons.org/licenses/by/4.0
Country	Canada; United States
Aggregated Source Repository	Dataverse

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CC-BY 4.0