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Regional antioxidant status in the gastrointestinal tract and the possible role of reactive oxygen-derived substances in peptic ulcer disease Moghadasian, Mohammed H.
Abstract
1. Enzymatic and non-enzymatic antioxidant profiles in the various segments of the gastrointestinal tract of male and female rats have been investigated and found to exhibit significant differences (P<0.05). In both sexes, the levels of basal glutathione in the gastric and colonic mucosa are comparable, but lower than those in the proximal and distal segments of the small intestine. The activities of glutathione reductase in various portions of gastrointestinal tract were similar. Glutathione peroxidase showed higher activity in the gastric mucosa than that in other parts of the gastrointestinal tract. No significant differences were found in the activity of superoxide dismutase among the various segments examined. 2. Enzymatic and non-enzymatic antioxidant profiles in the gastric and duodenal mucosa of rabbit, quail, cat, pig and rat have been investigated and found to exhibit significant differences (P<0.05). The levels of basal glutathione were highest in the rat gastric and duodenal mucosa when compared with those in other species. In the duodenal mucosa of all species investigated, the activity of glutathione reductase was higher than that in the corresponding gastric mucosa. The activity of glutathione peroxidase was higher in the gastric mucosa than that in other species examined. Superoxide dismutase showed higher activity in quail duodenal mucosa than in any of the other species studied. 3. The effects of 8% and undiluted ethanol administered by gavage on lesion formation and antioxidant components of the gastric and duodenal mucosa of male and female rats have been examined. Undiluted ethanol produced macroscopic lesions in the body of the stomach in association with decreases in the activity of glutathione reductase and in the level of basal glutathione and an increase in the activity of glutathione peroxidase. Eight percent ethanol produced a small but significant increase (12%) in the level of basal glutathione in rat gastric mucosa when compared with controls. 4. The effects of chronic intermittent stress on the appearance and antioxidant components of the gastric and duodenal mucosa of rats have been examined. No differences in the antioxidant profiles or evidence of macroscopic lesion formation were found.
Item Metadata
Title |
Regional antioxidant status in the gastrointestinal tract and the possible role of reactive oxygen-derived substances in peptic ulcer disease
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
1994
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Description |
1. Enzymatic and non-enzymatic antioxidant profiles in the various
segments of the gastrointestinal tract of male and female rats have been
investigated and found to exhibit significant differences (P<0.05). In both sexes,
the levels of basal glutathione in the gastric and colonic mucosa are
comparable, but lower than those in the proximal and distal segments of the
small intestine. The activities of glutathione reductase in various portions of
gastrointestinal tract were similar. Glutathione peroxidase showed higher activity
in the gastric mucosa than that in other parts of the gastrointestinal tract. No
significant differences were found in the activity of superoxide dismutase among
the various segments examined.
2. Enzymatic and non-enzymatic antioxidant profiles in the gastric and
duodenal mucosa of rabbit, quail, cat, pig and rat have been investigated and
found to exhibit significant differences (P<0.05). The levels of basal glutathione
were highest in the rat gastric and duodenal mucosa when compared with those
in other species. In the duodenal mucosa of all species investigated, the activity
of glutathione reductase was higher than that in the corresponding gastric
mucosa. The activity of glutathione peroxidase was higher in the gastric mucosa
than that in other species examined. Superoxide dismutase showed higher
activity in quail duodenal mucosa than in any of the other species studied.
3. The effects of 8% and undiluted ethanol administered by gavage on
lesion formation and antioxidant components of the gastric and duodenal
mucosa of male and female rats have been examined. Undiluted ethanol
produced macroscopic lesions in the body of the stomach in association with
decreases in the activity of glutathione reductase and in the level of basal
glutathione and an increase in the activity of glutathione peroxidase. Eight
percent ethanol produced a small but significant increase (12%) in the level of
basal glutathione in rat gastric mucosa when compared with controls.
4. The effects of chronic intermittent stress on the appearance and
antioxidant components of the gastric and duodenal mucosa of rats have been
examined. No differences in the antioxidant profiles or evidence of macroscopic
lesion formation were found.
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Extent |
5814861 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-03-05
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0087563
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
1994-11
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.