The Angiopoietin-Tie-2 axis in children and young adults with dengue virus infection in the Philippines

Mishra, Hridesh; Ngai, Michelle; Crowley, Valerie M.; Tran, Vanessa; Painaga, Maria Salome Siose; Gaite, James Yared; Hamilton, Patrick; Kain, Kevin C.; Hawkes, Michael T.

doi:10.14288/1.0448068

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The Angiopoietin-Tie-2 axis in children and young adults with dengue virus infection in the Philippines Mishra, Hridesh; Ngai, Michelle; Crowley, Valerie M.; Tran, Vanessa; Painaga, Maria Salome Siose; Gaite, James Yared; Hamilton, Patrick; Kain, Kevin C.; Hawkes, Michael T.

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Title	The Angiopoietin-Tie-2 axis in children and young adults with dengue virus infection in the Philippines
Creator	Mishra, Hridesh; Ngai, Michelle; Crowley, Valerie M.; Tran, Vanessa; Painaga, Maria Salome Siose; Gaite, James Yared; Hamilton, Patrick; Kain, Kevin C.; Hawkes, Michael T.
Contributor	Children's Hospital (Vancouver, B.C.). Vaccine Evaluation Center
Date Issued	2024-08
Description	Dengue virus (DENV) infection is associated with plasma leakage, which may progress to shock. The Angiopoietin (Ang)-Tie-2 axis regulates endothelial permeability. We examined the clinical utility of Ang-1, Ang-2 and the Ang-2:Ang-1 ratio for prediction of progression to severe DENV in a prospective cohort study of children and young adults (age 1 to 1 was associated with a relative risk of hospitalization of 1.20 (95% 1.03- 1.36, p=0.016). A higher Ang-2:Ang-1 ratio was associated with longer length of hospital stay, higher frequency of transfer to a higher-level facility, larger intravenous fluid requirement, hemoconcentration, and thrombocytopenia. Ang-2 was correlated with procalcitonin (Kendall’s τ =0.17, p=0.00012), a marker of systemic inflammation, as well as sVCAM-1 (τ =0.22, p
Subject	dengue virus infection; angiopoietin; endothelium; shock
Genre	Article; Postprint
Type	Text
Language	eng
Date Available	2025-08-13
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0448068
URI	http://hdl.handle.net/2429/90368
Affiliation	Medicine, Faculty of; Non UBC; Pediatrics, Department of
Citation	Mishra H, Ngai M, Crowley VM, Tran V, Painaga MSS, Gaite JY, Hamilton P, Kain KC, Hawkes MT. The Angiopoietin-Tie-2 Axis in Children and Young Adults with Dengue Virus Infection in the Philippines. Am J Trop Med Hyg. 2024 Aug 13;111(4):887-896.
Publisher DOI	10.4269/ajtmh.24-0115
Peer Review Status	Reviewed
Scholarly Level	Faculty; Researcher
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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