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Doelman, Adam Willem

University of British Columbia

The impairment of lower urinary tract (LUT) function remains one of the most significant contributors to morbidity and secondary complication following traumatic spinal cord injury (SCI). Presently, the clinical-standard for the assessment of LUT dysfunction after SCI is urodynamic studies (UDS); however, this technique presents many well-recognized shortcomings, particularly the use of transurethral catheters and artificial bladder filling which may interfere with LUT function and the interpretation of subsequent UDS results. There is therefore an appreciable need to develop alternative devices and techniques to provide a more accurate and reliable assessment of LUT dysfunction after SCI without the use of catheters. To address this, I tested and helped develop two wireless, catheter-free pressure sensors for the assessment of LUT function in humans and large animals. Wireless devices present many advantages over catheter-based approaches. Notably, they enable continuous assessment of dysfunction over a period of several hours or days outside of the clinical setting which can provide a more representative evaluation of a patient’s “normal” LUT function. Through these pre-clinical studies, I have tested and validated two novel wireless bladder pressure monitoring devices to assess LUT dysfunction after SCI in animals and humans. These findings may help accelerate the implementation of wireless pressure sensors to assess urinary dysfunction in human subjects living with SCI and provide a reference dataset for future work as well as for correlative pig-human investigations.

Text

2024-10-10

Attribution-NonCommercial-NoDerivatives 4.0 International

http://hdl.handle.net/2429/89383

Neuroscience

University of British Columbia

UBCV

http://creativecommons.org/licenses/by-nc-nd/4.0/