UBC Undergraduate Research

Whipping Out Bacteria : A New Era of Flagellum-Targeted Therapeutics Kanani, Sahil; Yang, Kaitlyn; Kalsi, Pavneet


The bacterial flagellum enables bacterial motility and is important in enhancing the virulence or ability of bacteria to cause disease. Bacteria such as E. coli and Salmonella typhi are known to rely on their flagella to attack multicellular organisms, making it an important target when considering potential treatments for infection. This project seeks to determine the structure of flagellar proteins responsible for bacterial motility and proposes a structure-based drug design that utilizes the flagellar stator as a novel drug target for antibiotics.

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