UBC Undergraduate Research

Effects of Intravenous Lidocaine Infusions on Pain and Opioid Consumption after Pediatric Scoliosis Correction… Lee, Michelle; Yeung, Shanna 2016-03-30

Your browser doesn't seem to have a PDF viewer, please download the PDF to view this item.

Notice for Google Chrome users:
If you are having trouble viewing or searching the PDF with Google Chrome, please download it here instead.

Item Metadata


42446-Lee_M_et_al_Effects_MURC_2016.pdf [ 1.08MB ]
JSON: 42446-1.0379173.json
JSON-LD: 42446-1.0379173-ld.json
RDF/XML (Pretty): 42446-1.0379173-rdf.xml
RDF/JSON: 42446-1.0379173-rdf.json
Turtle: 42446-1.0379173-turtle.txt
N-Triples: 42446-1.0379173-rdf-ntriples.txt
Original Record: 42446-1.0379173-source.json
Full Text

Full Text

Effects of Intravenous Lidocaine Infusions on Pain and Opioid Consumption after Pediatric Scoliosis Correction Surgery Michelle Lee, Shanna Yeung Faculty of Science, University of British Columbia, Vancouver, Canada »  Background: Scoliosis, a spine deformity, most commonly affects adolescents. Patients undergoing scoliosis correction surgery experience severe post-operative pain. [1] »  Problem: Pain is typically controlled with high doses of intravenous (IV) opioids. » Can cause side effects including nausea and respiratory depression. [2] » Decreasing opioid consumption, while sufficiently numbing pain, might improve patient recovery.  »  Potential solution: Administration of IV lidocaine has been shown to reduce post-surgical opioid consumption in adults, without causing major adverse effects. [3] »  In adult patients undergoing abdominal, orthopedic, cardiac, or ambulatory surgery »  10/16 studies showed significant reduction (ranged from 33%-85%) of opioid consumption with lidocaine infusion. »  6 studies showed significant reduction of pain scores with lidocaine infusion. Introduction »  To investigate whether lidocaine infusions are beneficial to pain management after pediatric scoliosis correction surgery. Specifically, 1.  Reduced opioid consumption by 35% [3] 2.  Reduced pain score, measured by Color Analogue Scale, by 1 unit. Study Aim »  We expect lidocaine infusions to decrease post- surgical pain severity and opioid consumption by about 35%.  [1] Global Spine J. 2013; 3(1):7-14 [2] Pain Physician. 2008; 11(2 Suppl):S105-20. [3] Drugs 2010; 70(9):1149-63 [4] Proc Intern Symp Ped Pain. 2015;P2-23 References Methods »  Dr. Matthias Görges, Department of Anesthesiology, Pharmacology and Therapeutics, UBC Acknowledgment »  Recruit 60 adolescents (12-18yrs) undergoing posterior spine surgery »  Obtain research ethics board approval, written consent and age-appropriate assent »  Randomize into three groups 1.  No lidocaine infusion 2.  Lidocaine infusion during surgery 3.  Lidocaine infusion continued till 24hrs after surgery »  Recorded Measurements »  Opioid consumption  »  Sum of continuous IV and patient controlled analgesia (PCA) »  Report in 12-hours interval, for 72hrs »  Measure pain score using color analogue scale (CAS)  »  Obtain in 2-hours interval (if awake), for 72hrs Expected Results Preliminary Results [4] »  A retrospective case-matched study on the effect of IV lidocaine in children undergone idiopathic scoliosis correction surgery. [4] »  24 patients (Aged 16.4 ± 1.9 years) »  12 received IV lidocaine Infusion during surgery »  12 matched controls »  Post-Operative morphine utilization was measured every 2 hrs for 48hrs. »  Morphine consumption in lidocaine group was reduced by 19%. »  No significant differences in times to: a)  Documented first stand  b)  Urinary catheter removal c)  Discharge from hospital Fig 1.  Post-Operative Morphine Utilization [4] 60 patients 1.5 mg/kg Lidocaine intravenously  1.5 mg/kg Lidocaine intravenously  Obtain consent  & assent 20 patients 20 patients 20 patients Randomize Pain is measured using VAC: Postoperative opioid  consumption measured: 0 24 48 72 hrs Lidocaine Infusion:  2-2.5mg/kg/h Surgery Lidocaine Infusion:  2-2.5mg/kg/h Hours after surgery: 12 36 60 0 12 24 36 48 60 72 hrs Surgery Surgery Data Analysis: Plot as box plots and compared using pair-wise Wilcoxon rank-sum test.  


Citation Scheme:


Citations by CSL (citeproc-js)

Usage Statistics



Customize your widget with the following options, then copy and paste the code below into the HTML of your page to embed this item in your website.
                            <div id="ubcOpenCollectionsWidgetDisplay">
                            <script id="ubcOpenCollectionsWidget"
                            async >
IIIF logo Our image viewer uses the IIIF 2.0 standard. To load this item in other compatible viewers, use this url:


Related Items