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Understanding the Roles of Insulin Signalling and Type-2 Diabetes in Pancreatic Intraepithelial Neoplasia… Magrill, Jamie 2018-03-17

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Understanding the Roles of Insulin Signalling and Type-2 Diabetes in Pancreatic Intraepithelial Neoplasia Formation  Jamie	Magrill,	Honors	Biology	(BIOL449)	March	17	2018	Supervisor:	Dr.	James	Johnson	                                        Disciplines We Will Be Integrating Today Visual Arts! Biological Sciences Medicine Statistics Economics! Social Media/Social Sciences! Context: Why Study Diabetes and Pancreatic Cancer? •  Pancreatic cancer is the 4th leading cause of cancer death in Canada, 5-year  survival less than 2% •  Diabetes affects more than 400 million people worldwide and is a risk factor  for pancreatic cancer   Introductory Axioms 1) Elevated insulin levels have been proven to have tumorigenic effects 2) Previously observed link between likelihood of pancreatic cancer and diabetes progression Axiom 1: Insulin and Cancer Axiom 2: Pancreatic Cancer and Diabetes Ins1 +/+ (High Insulin) Ins1 +/- (Low Insulin) What is Pancreatic Intraepithelial Neoplasia? Noë M, Lodewijk AAB. Pathology of Pancreatic Cancer Precursor Lesions. Surg Pathol Clin. 2016;9(4):561-580. Preliminary Data – Precursor Lesion Area (High Insulin) (Low Insulin) (Low Insulin) (High Insulin) Unpublished data, A. Zhang  n= 9 Interactive Art and Social Media Activity! Interactive Art and Social Media Activity! Normal Acinar Cells Only circle the Precursor Lesions! Reducing Interobserver Variability: Alcian Blue Staining PanINs Stain Darkly Blue Internal Control: Intesine Results (Low Insulin) (High Insulin) Unpaired t-test: p=0.3068 n= 9 (High Insulin) (Low Insulin) Future Directions and Take Home Message •  Faster and less invasive diagnosis  for diabetic and prediabetic patients •  Clearer understanding of the role of  insulin in pancreatic cancer formation •  Improve quantification, increase  sample size and investigate signaling pathways downstream of the insulin  receptor Acknowledgements Areas Integrated: Visual Arts! Biological Sciences Medicine Statistics Economics! Social Media/Social Sciences! Johnson Lab: Dr. James D. Johnson, Ph.D. (Group Leader)  Dr. Evgeniy Panzhinskiy, Ph.D. (Post-doctoral Fellow)  Dr. Søs Skovsø, Ph.D. (Post-doctoral Fellow)  Dr. Honey Modi, Ph.D. (Post-doctoral Fellow)  Dr. Jelena Kolic, Ph.D. (Post-doctoral Fellow)  Dr. Diego Bottezelli, Ph.D. (Visiting Post-doctoral Fellow)  Ms. Leanne Beet, B.Sc. (Staff & Lab Manager)  Ms. Betty Hu, M.Sc. (Staff) Mr. Peter Oversby, M. Sc. (Staff) Mr. Howard Cen, B.Sc. (Graduate Student)  Ms. Stephanie Marcil, B.Sc. (Post-graduate Student)  Ms. Anni Zhang, B.Sc. (Graduate Student)  Mr. Sepehr Kamal, B.Sc. (Graduate Student)  Mr. Jamie Magrill (Undergraduate Student) Kopp Lab: Dr. Janel Kopp, Ph.D. (Group Leader)  Ms. Atafeh Samani, B.Sc. (Graduate Student) Ms. Soheila Rad (Graduate Student) Mr. Andy Wang (Graduate Student) Ms. Farnaz Taghizadeh, M.Sc. (Staff and Lab  Manager) Ms. Emma Croft (Undergraduate Student) 

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