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UBC Theses and Dissertations
Design and validation of a sinonasal endoscopic score (SiNES) for chronic rhinosinusitis outcome assessment Hernaiz Leonardo, Juan Carlos
Abstract
Chronic rhinosinusitis (CRS) is a debilitating disease that affects the sinonasal cavity and significantly reduces patients’ quality of life. Sinonasal endoscopy is the main strategy for evaluating and monitoring CRS patients. There are several endoscopic grading systems available, but they all have important shortcomings and limitations. There is an urgent need for a reliable score that can accurately reflect patient’s disease burden that is easy to use and applicable to all CRS subtypes. In chapter 1 of this thesis, I review the main endoscopic scoring systems and describe their main advantages and disadvantages. Based on these findings, Chapter 2 describes the design and validation of the SiNonasal Endoscopic Score (SiNES), a new scoring system that incorporates the strengths of previous scores while addressing their limitations. This chapter further investigates the relationship between the newly developed SiNES and patient reported outcome measures (PROMs). Chapter 3 explores the minimal clinical important difference (MCID) for the SiNES. This chapter incorporates the perspectives of both surgeons and patients and produces an MCID value that can be used for clinical trial development and patient monitoring. Chapter 4 further validates the SiNES using data from the first 45 participants in the SinoNasal Microbiota Transfer (SNMT) trial, a landmark study that will determine whether SNMT can improve the health of recalcitrant CRS patients. The chapter includes data on how the SiNES correlates with objective olfactory outcomes, quality of life measures, and a diverse set of type 2 and non-type 2 cytokines. Finally, Chapter 5 consolidates the findings of the entire thesis and gives some perspectives on future research directions.
Item Metadata
| Title |
Design and validation of a sinonasal endoscopic score (SiNES) for chronic rhinosinusitis outcome assessment
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| Creator | |
| Supervisor | |
| Publisher |
University of British Columbia
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| Date Issued |
2025
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| Description |
Chronic rhinosinusitis (CRS) is a debilitating disease that affects the sinonasal cavity and significantly reduces patients’ quality of life. Sinonasal endoscopy is the main strategy for evaluating and monitoring CRS patients. There are several endoscopic grading systems available, but they all have important shortcomings and limitations. There is an urgent need for a reliable score that can accurately reflect patient’s disease burden that is easy to use and applicable to all CRS subtypes.
In chapter 1 of this thesis, I review the main endoscopic scoring systems and describe their main advantages and disadvantages. Based on these findings, Chapter 2 describes the design and validation of the SiNonasal Endoscopic Score (SiNES), a new scoring system that incorporates the strengths of previous scores while addressing their limitations. This chapter further investigates the relationship between the newly developed SiNES and patient reported outcome measures (PROMs).
Chapter 3 explores the minimal clinical important difference (MCID) for the SiNES. This chapter incorporates the perspectives of both surgeons and patients and produces an MCID value that can be used for clinical trial development and patient monitoring.
Chapter 4 further validates the SiNES using data from the first 45 participants in the SinoNasal Microbiota Transfer (SNMT) trial, a landmark study that will determine whether SNMT can improve the health of recalcitrant CRS patients. The chapter includes data on how the SiNES correlates with objective olfactory outcomes, quality of life measures, and a diverse set of type 2 and non-type 2 cytokines.
Finally, Chapter 5 consolidates the findings of the entire thesis and gives some perspectives on future research directions.
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| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2025-04-29
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0448642
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| URI | |
| Degree | |
| Program | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
2025-11
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| Campus | |
| Scholarly Level |
Graduate
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International