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UBC Theses and Dissertations
Characterization of a novel family of repressors affecting many processes during Arabidopsis thaliana seed development Hoy, Ryan
Abstract
The seed is a vital component of the plant life cycle and an innovative strategy that plants use to reproduce and survive through extended periods of adverse environmental conditions. The processes involved in the development of the seed are highly complex, and one novel clade of genes that was identified to play a role in controlling the genetic network of seed development is the DYNAMIC INFLUENCER OF GENE EXPRESSION (DIG) clade. Using genetic strategies including Yeast 2 Hybrid and a mutagenesis screen, I worked to elucidate the mechanisms behind the DIG clade’s regulation of this genetic network. My proposed model shows that through protein-protein interactions, transcription factors can recruit DIG proteins to target genes, and in turn DIGs interact with VP1/ABI3-LIKE 2 (VAL2) which recruits the Polycomb Repressive Complexes 1 and 2 to regulate the target genes expression through chromatin modifications.
Item Metadata
| Title |
Characterization of a novel family of repressors affecting many processes during Arabidopsis thaliana seed development
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| Creator | |
| Supervisor | |
| Publisher |
University of British Columbia
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| Date Issued |
2022
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| Description |
The seed is a vital component of the plant life cycle and an innovative strategy that plants use to reproduce and survive through extended periods of adverse environmental conditions. The processes involved in the development of the seed are highly complex, and one novel clade of genes that was identified to play a role in controlling the genetic network of seed development is the DYNAMIC INFLUENCER OF GENE EXPRESSION (DIG) clade. Using genetic strategies including Yeast 2 Hybrid and a mutagenesis screen, I worked to elucidate the mechanisms behind the DIG clade’s regulation of this genetic network. My proposed model shows that through protein-protein interactions, transcription factors can recruit DIG proteins to target genes, and in turn DIGs interact with VP1/ABI3-LIKE 2 (VAL2) which recruits the Polycomb Repressive Complexes 1 and 2 to regulate the target genes expression through chromatin modifications.
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| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2024-05-31
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0422371
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| URI | |
| Degree | |
| Program | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
2023-05
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| Campus | |
| Scholarly Level |
Graduate
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International