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Y-box binding protein-1 (YB-1) is a bio-marker of aggressiveness in breast cancer and is a potential.. Habibi, Golareh 2008

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Y-I OI1 (Y1IS A O-MAEOAGGSSISS IEASCAEA IS A IAEEUC IEEIOGOSc(MaiogyCe ogy a Gecs Oioe Ui oisComaA ESIS SUIEIIAE OE QUIE E GE OMASOSCIEEiE CUY OGA SES(Ieiscii OogyE US OISCOMAOUua oAACEay cois o oe mosima c successeae ocae Cuescieis a sea mocumae aca iia ecouome a ce ocuee iesIis swe moae iaimcoY-i oi1 (Y1as a maeoaggssissa caecuee ieasmagies  sce o oe esssuemicaays iAmecaY1 is aoogec acioaoc wcis oesseie ma omagiesi eascae Ie co o imaeasmouwe sw aY1 is a so maeoaggssissosuia caecuee ia suys omaeascaewi a icuy gequey oessioie Ega sake a eascaesuysis sugges ae Y1 may o a w ae euc ieeioiese eascae aa cue cei  ea Cogssiomuiaasis iicas aY1 is seco oy  ss as a so ieeogsc maeoouome a e com esiscco-ogicaomaei mousiagegEa ssisi sugges aY1 s gaia  ia io soomae iii e es wi a gsk oe a oouomeSuequewe aassociaoeeY1 a ukise asmigeAc(uessioie sake suyWe esw aY1 is ioeieguoou essio Mo imasii Y1 ou sus iasigca coicaece iasio As e a  commeiay aie Y we emie eicacy oS-53a sma mocu iiacIG1IoSUM1 cesWe moa aacIG1isassociawi osuiiima easmou aaS-53 cesu essiougiioY1 iSUM1 cesWe e co aY1 is a o-maeosuia eWe ao iica aY1 s iause as a mocumaeia ccaseiIi Y1 may o aiaoou ee ieascaeii111E OCOESAAC ^ iiE OCOES ^ iiiSOES ^ iSOGUS ^ AEAO ^  iACKWEMES ^ CAO ^ iCO-AUOSME ^ iiCE1- ICO ^ 11 eascae ^ 11 equey a ogi ^ 11 Cssicaooeascae ^ 1 Sa eaes oeasCae ^ 31 Cmoe ^ 31 ee ^ 1 ceosi kises ^ 51 Eagw cceo(EG ^ 1 e oogec oy oEG ^ 71  EG ie oeascae ^ 71 EG as a eai-caee ^ 1 maeeagw cceo( ^ 91 e oogec oy o ^ 11 as a ogsc a ec iica ^ 11 as a eai-caee ^ 111 Oeai-caeugs agaimi Ks ^ 111 Iugw cceo(IG mi ^ 11 IG1sig casca ^ 11  oIG1ieascaeogssio ^ 131 IG1as a ecaee ^ 1i1 Aies agaiIG1 ^ 11 Sma mocu ii agaiIG1 ^ 11 wseam sua oKs wca iaeuc e  ^ 151 Ukise asmigeac(u ^ 151 oisuc a o ^ 151 u a eascae ^ 11 u as a ecaee  ^ 171 Y-i oi1 (Y1 ^ 171 Ge suc a essio ^ 11 oisuc a o ^ 11 o oY1   ^ 191  oY1 as a acioc ^ 191  oY1 as a aoc ^ 1  oY1 iug sise  ^ 1 Y1 a eascae ^ 1 esis esis  ^ 1 esis oecs  ^ 1 es  ^ CEEagw cceo(EGis 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a K sigway  ecices aoess (ick ea ; ickea 11 e oogec oy oOgiy o ea (19sweae g o b2  ocassociawi mag aaoo ces we oeeimamamma mouces aoessee ge ( o ea 19 Suequeaes  e same gu e a b2  ge was iceioimmoamamamma eeaces (1 acocoeeagw aaage  ese ces    vr a   v (ee ea 1991 Oessioa/oge amicaoowas cima s omamagy a icuy imaeascae w  b2  ge amicaos eu wi a equey oama u 3 (Smoea 19;Smoea 19 ik eai199ao eaaoae o eiewi owiouge amicao is associawi osuiaaggssiss ies wi eascae(ik ea 199 ick ea 1 as a ogsc a ec iicaIaeeacese essioois  w weoessiooamicaoowas cie omamagies sucas eas ae gasickiey a oacaimas(s ea 199Smoeai19 eaicuy ies wi eascae aoess  mucsesuime com ees aess ae a(Smoea 19 oas  Yu easws aoessioois associawi e mom  messes i-si eascaees (Yu ea Moo iaaeeascae g ociu eceumaiois associawi cee eicacy oceaicmoe como(Comeea  Mosy imais aiee ec maese  ai-esogeugsuseai1999 sweaoessiois associawi ck ose  eoc e ies wiaaeEsi eascae(usea 1999; ick ea 111 as a eai-caeee a ma aacs was ii measig (e ea  Ses  iak ea(19a S ea1991 sweaMA5a mocai e e eceumaio cee gwooessi ce s a iimougw   v (iak ea19; S ea 1991 ei(asmaauma ioomuMA 5  Geec was a e US oa ugAisao(Ai199as a  oeae womewi mesceascae(gm ea 199Seses eau 15 oossi eascaees w ceiasmaas a si-age ieieae gime se is ug (sea ea 199 Coeigea 1999we asmacomwi cociwi cycosamisigca iasee ee suime oeessi mesceascaees (is ; Si ea ; ick ea 1 Oeai-caeugs agaimi Kse  ck oeiciey a e ssie ce o sise geoasmaas a si ageaaceucacomes ugsae EG a  ao kwas GW571 is aai-caeug  GSmiK eae oeasa  caeeseA aioMa13ea es wi aaemesceascaeicomowi ceaicmoe ugsis aeagw cceo(EGa u (E asi kise ii(a ea  Is  e iceumai iiceoauosoouga ie eci si scue ecoie a easweaii ceoosoo ocks MA sig casca a e ces e gw oEG ooessi ce s (a ea  Seses seeecoicomowi oeugs  ice s a imousegieicomowi 3K ii syiscay iuceaosisIaio e imoai-mouac   v1was oeewwas usewi coci(CI-13 is ao ae osi kise iiae EGa (Aeea  CI-13 ieiy ii ga-smuosoooe ceo i  a coeecysi sie ie Ai si ie si kise mai(Scyeea  is ug caiuce 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s17 yeais eeaIGIa i gas a ioeie a ogssiooma mamagies suceasa oscae(s ea ; s ea  A   Se ea (1993iicaamouse oasces wi gec ooIG1seiai aesuess IG1was sy iceio e oas (Se ea 1993Sueque Aes eai s swasi osoooI-1a acooe 3K way seems   cciae a oIG1a ces (Aes ea  Iaio iiooIG1omi ga musaies agaiIG1 oaisee aacseemougw   vrd  v (Aeaga ea 19; Sa ea AcooIGIway ao smus mo oeascaeces   vrsugges a  is sysm imessisA mos iicaaocki oIG1sus isigca coiiasioa messis oeascaima ces ( ea 199 Saceea   eai199sweaasoeuaIG1(caes ca iei a ema scoaami acisussee iasioa messis oM-M5 ces (ea 199Aes  Saceea (iusaaa C-iyuami ga IG1sigca iiiasioa messis oM-M35/Cces   (Saceea 11 IG1as a ecaeeCuee a o e aacs was ii IG1aco1Aies as  eceumaioIG1a  Sma mocuii aock e kise ac oe ceo1 Aies agaiIG1Semocaies cagaiIGI ecasucasC7511 om i IMC-A om ImcSysms19om Sc-oug E om ImmuGeAisa 7C1om ee e/Me(m ea ; Gae; Goecea ; e ea ; May ea; Wa ea  Cuea aies seem  wo ia simimaewcis i  eceuga i maia su iwguooIGI Augi oIG1 sus iceocycmocaii a  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1995 eu ays a  ima  icaeeiasioa messis (y ea e mosima ii oukise a asmigeacii1(I-1a asmigeacii(I-wciie oase acieiy I-1 a I-  se oase iimi wca asuami ooi a io a coeesuc a moa a sciasuici sua-ke iiomecsm (Sieaea ; y ea 1 u a eascaeg ou ieasmou ec osui(cke ea 19;ok ea  Ieemeamo oeascae u iases ce migo(uyeea a messis (Yu ea 199Cois wi isiioou cases mougw a messis (Guo ea  Imau is aosigca associawi a g oe es wi eascae(cke17ea 19 e EuaOaoseaa eae oCaegau as a I cago omaecaea e w ages e isoase wou cay  cia(eck ea ; s Saos ea 1u as a ecaeeSagies  iiu i aogaoou oase ac (Weeaa sioou i  i ceo(Guo ea  Aacs iiu oco sueisussioocaee amessis sugges ais cou  aima eeuc ieeioiesii u usi sma iee A (siAii e gw oos caece s (ku ea  e i iiA aicuy  e ami acisequee cciau    u s moaomisi sus iase I ccases ioacae(eea  Iaio oeugs sucas 17-aymi geamyci(17-AAG(eeeaa ceco(Aws ea we sw iiu ocoss ey a e uoa cyci oems e ea some mio eiuse ie cc (s Saos ea Ouam eous eae uguoou  IG1s oa coeee o3K/Aka MA waysa  e acooe u( ea 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