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Wu, Angeline

Angeline Wu was a finalist in the 2024 UBC Three Minute Thesis (3MT) competition. Angeline presented their research, "When Sugar Isn't Sweet: Glycosylation in Rheumatoid Arthritis." They hope to alleviate pain from bending the knee or twisting the wrist by leveraging CRISPR activation and fluorescent proteins to stop immune attack. Patients with rheumatoid arthritis can experience burning pain and stiffness in their joints due to their own immune system attacking their own joints. Current medications only work to lessen symptoms or suppress the immune system as a whole. Interestingly, there are immune system sugar patterns that are only found in rheumatoid arthritis patients. These “bad sugars” mark receptors in the joints, alerting the immune system to attack the joints. Using a novel technology called CRISPR activation, it may be possible to find out exactly what receptors the “bad sugars” are marking. This will allow for more targeted treatment through blocking the receptors that are being marked, and therefore prevent the root cause of disease in rheumatoid arthritis. Angeline Wu is completing their Master of Science in Pharmaceutical Sciences in the Faculty of Pharmaceutical Sciences under the supervision of Dr. Simon Wisnovsky.

Moving Image; Text

Three Minute Thesis (3MT)

Vancouver : University of British Columbia Library

10.14288/1.0447817

Pharmaceutical Sciences, Faculty of

Graduate

DSpace