Open Collections

UBC Graduate Research

Office politics : Studying dominant negative mutations in DNA2 to improve cancer treatment Baillie, Katherine

Description

Katherine Baillie was a finalist in the 2024 UBC Three Minute Thesis (3MT) competition. Katherine presented their research, "Office politics: studying dominant negative mutations in DNA2 to improve cancer treatment." They hope to identify dominant negative mutations in the DNA repair gene DNA2 to develop targeted anti-cancer therapies, improving cancer treatment efficacy. Cancers rely upon effective DNA repair for their survival. This makes the genes involved in DNA repair promising targets for future therapies. Katherine is investigating one such potential therapy targeting a gene called DNA2. To model this therapy, she is studying dominant negative mutations, which actively sabotage DNA repair. This work is supported by the Canadian Cancer Society. Cartoon depictions created with BioRender.com. Katherine Baillie is completing their PhD in Interdisciplinary Oncology in the Division of Medical Oncology under the supervision of Dr. Peter Stirling.

Item Metadata

Title
Office politics : Studying dominant negative mutations in DNA2 to improve cancer treatment
Creator
Baillie, Katherine
Date Issued
2024-03-12
Description
Katherine Baillie was a finalist in the 2024 UBC Three Minute Thesis (3MT) competition. Katherine presented their research, "Office politics: studying dominant negative mutations in DNA2 to improve cancer treatment." They hope to identify dominant negative mutations in the DNA repair gene DNA2 to develop targeted anti-cancer therapies, improving cancer treatment efficacy. Cancers rely upon effective DNA repair for their survival. This makes the genes involved in DNA repair promising targets for future therapies. Katherine is investigating one such potential therapy targeting a gene called DNA2. To model this therapy, she is studying dominant negative mutations, which actively sabotage DNA repair. This work is supported by the Canadian Cancer Society. Cartoon depictions created with BioRender.com. Katherine Baillie is completing their PhD in Interdisciplinary Oncology in the Division of Medical Oncology under the supervision of Dr. Peter Stirling.
Genre
Presentation; Other
Type
Moving Image; Text
Language
eng
Series
Three Minute Thesis (3MT)
Date Available
2025-01-21
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0447794
URI
http://hdl.handle.net/2429/90159
Affiliation
Medicine, Faculty of
Peer Review Status
Unreviewed
Scholarly Level
Graduate
Rights URI
https://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International