UBC Graduate Research

Disarming C. difficile : The fragmented approach Al-Emadi, Nada

Description

Nada Al-Emadi was a finalist in the 2024 UBC Three Minute Thesis (3MT) competition. Nada presented their research, "Disarming C. difficile: The Fragmented Approach." They hope to provide hope for C. difficile patients by making effective treatments accessible and affordable, and to ensure a future where everyone can take antibiotics without worrying about getting a C. difficile infection. C. difficile infections are a major healthcare concern, often occurring after antibiotic treatment disrupts the gut microbiota. Current treatments rely heavily on antibiotics, which are becoming less effective due to the rise of antibiotic-resistant bacteria. Antibody therapy offers a promising alternative, as it effectively neutralizes the toxins produced by the bacteria. However, traditional antibodies are not accessible to all patients due to their cost, difficult production, and side effects. To address these issues, Nada’s research focuses on using antibody fragments, which are more cost-effective, easier to produce, and have fewer side effects than traditional antibodies, while retaining toxin-neutralizing ability. Nada is testing these fragments on cells for toxin neutralization and will then evaluate their effectiveness in C. difficile-infected mice. Nada Al-Emadi is completing their Master of Science in Population and Public Health in the School of Population and Public Health under the supervision of Drs. Ted Steiner and Laura Sly.

Item Citations and Data

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International