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Physical Therapy Exercise Interventions in Tendinosis Injuries Brown, Paul; Lazjerowicz, Cleo; Martin, Aislin; Phillips, Margaret; Yeates, Michelle; Li, Linda Jul 30, 2007

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Tendinopathy and the Effectiveness of Eccentric Exercise A Systematic Review By: Aislin Martin Cleo Lajzerowicz Michelle Yeates Maggie Phillips Paul Brown Supervisor: Dr. Linda Li  Overview ¾ ¾ ¾ ¾ ¾ ¾ ¾  Purpose Introduction Methods Results Discussion Clinical Relevance Future Research  Purpose To systematically review the current evidence and determine the effectiveness of eccentric exercise in the treatment of chronic tendinosis  Introduction Tendinosis: ¾ a non-inflammatory intratendinous collagen degeneration without clinical or histological signs of inflammation1,2 Common tendons affected: ¾ patellar, Achilles, tendons of the medial and lateral elbow, rotator cuff2  Introduction Prevalence ¾  Elite male volleyball players z  ¾  General population z  ¾  incidence can be as high as 40% 4, 5  Elite and recreational runners z  ™  lateral epicondylitis annual incidence is between 1% -3%4,5  Competitive tennis players z  ¾  40% to 50% patellar tendinosis 3  Achilles tendinopathies accounts for 9% of injuries 6  Overuse injuries, including tendinopathies, account for nearly 7% of all injury related physician office visits in the United States 7  Introduction Common causes1: Aging ¾ Microtrauma ¾ Vascular compromise ¾  Common population3-7: Competitive and recreational athletes ¾ People in occupations consisting of repetitive tasks or manual labor ¾  Recovery times with treatment1: Early presentation: 6-10 weeks ¾ Chronic presentation: 3-6 months ¾  Introduction Histological Findings 1,2,4,8,9 ↑ cellularity - fibroblasts and myofibroblasts ¾ ↑ vascularity and ground substance ¾ Collagen disorientation, disorganization, focal necrosis or calcification, vascular spaces with or without neovascularization and fiber separation ¾ Absence of inflammatory cells ¾  Normal  Introduction Conservative Treatments1-8 ¾ ¾ ¾ ¾ ¾ ¾  Ultrasound ¾ Laser ¾ Deep friction massage ¾ Orthotics and braces ¾ Corticosteroids ¾ Mobilizations and manipulations ¾  Thermotherapy Cryotherapy Rest Acupuncture Pulsed electromagnetic field therapy Eccentric exercise  Introduction Eccentric Exercise ¾  The active lengthening of a muscle under force10  Introduction ¾  Eccentric training leads to increased net collagen synthesis in the tendon tissue through constant overload on the tendon11  ¾  12 weeks of EE training normalized tendon structure and decreased tendon thickness in Achilles tendinosis12  Introduction RATIONALE ¾ The literature shows that eccentric exercise has promise for treatment of Achilles and patellar tendinopathies GOAL ¾ Review the literature to examine the effectiveness of eccentric exercise as a treatment for tendinosis  Methods  Methods: PICO P  I  ¾Patients  diagnosed with a tendinopathy (eg. clinical exam / MRI / Ultrasound / Doctor) or chronic painful tendon greater than 3 months ¾Adults 16 years or older ¾Eccentric  C  ¾none  O  ¾Pain  exercise  ¾ROM ¾Return  to functional activities ¾Avoid surgical intervention ¾Strength ¾Tendon structure/healing  Methods: Search Strategy Databases ¾ ¾ ¾ ¾ ¾ ¾  EMBASE CINAHL MEDLINE PEDro Cochrane library SPORTDISCUS  Other Forms ¾  Hand searching Journals z  ¾ ¾ ¾  Physiotherapy, Physical Therapy  Reference lists Personal libraries Communicating with experts in the field z  Doctoral candidate (Michael Ryan)  Methods: Search Strategy ¾ Main z  z  z  Terms  Tendinopathy, tendinosis, tendon disease, tendon injury Achilles, swimmers shoulder, patellar tendon, golfer’s elbow, rotator cuff, jumper’s knee Eccentric exercise  Search Terms 1  2  3  4  Tend#n  5 6  Table of Search Terms  12  Golfer’s  Tend#n  13  Patella$ tend$.mp  Swimmer’s  14  Jumper’s  15  Achilles tend$.mp  16  7  Rotator cuff tend$.mp  8  Shoulder  17 or Exercise/  9  Medial epicondyl$  18  Or/ 1-15  19  16 and 17  20  18 and 19  21  Limit 20 to (human and English language)  10  11  Tennis elbow/or medial epicondyle$ Tennis elbow/or lateral epicondyle$  Methods: Study Selection Inclusion Criteria ¾ 16 years or older ¾ Clinical diagnosis of tendinopathy or: ¾ Tendon pain for > 3 months ¾ English studies ¾ Eccentric Exercise  Exclusion Criteria ¾ Concurrent treatment ¾ Surgical intervention ¾ Tendinosis caused by injection  Methods: Study Selection Study Selection ¾ Screen of title and abstracts ¾ Selection of articles based on inclusion criteria z  2 person independent review  ¾ Recovery z  and review of full articles  Random allocation to 2 persons for independent review  Methods Study Selection ¾ Pilot the data extraction form z  z  Modified data extraction form provided by Dr. Linda Li 10% of articles were tested using the form • 89.6% based on 115 variables  z  Changes were made to the form to increase accuracy and consistency  Methods Data extraction Study description ¾ Participant description ¾ Study quality rating (van Tulder13) ¾ Baseline and post treatment outcome measurements ¾ Dropouts, adverse effects ¾  Methods: Quality of Studies ¾  Used Van Tulder13 Quality Assessment z 11 criteria rated: Yes, No, Unclear  ¾  Methodological criteria were independently assessed by 2 reviewers  9  Consensus reached by discussion  ¾  High Quality = Score of 6 of 11 or above Low Quality = Score 5 and below  ¾  Methods: Quality of Studies ¾  Less than 1/3 of the studies fulfilled all of the following criteria: z  ¾  adequate treatment allocation concealment, blinding of patients, and blinding of the care provider  Less than 1/2 of the studies blinded the outcome assessor to the intervention or had acceptable compliance (> 70%) in all groups.  Methods ¾  Standard mean differences: Hedge’s G z  ¾  Studies with similar outcome measures  Best evidence synthesis14 z  z  Rates studies according to whether: Strong, moderate, limited, indicative, no evidence Utilizes study design (RCT, CCT, other design), study quality (high/low), statistical findings  Results  Study Selection 201 citations  16 relevant articles  Search of databases: (n =201) EMBASE [56] Sp ortdiscu s [48] CINHAL [47] MED LINE [41] Coc hra ne Libra ry RCT [13] PED ro [5]  Duplicate a rticle s e xclu de d: (n = 91)  Article s e xclu de d base d on title /a bstract (n = 80)  Article s retrie ve d for de taile d eva luation (n = 30)  Excluded articles: (n=29) Adde d studie s ba sed on pe rsona l libra rie s, c hecke d re fe re nces a nd ha nd sea rc hing: (n = 15)  -Not a n RCT or CCT (n=18) -Fa ile d e ligibility c riteria (n=8) -No ecce ntric e xe rcise inte rve ntion (n= 1) -La ngua ge (n=1) -Not fou nd (n=1)  Final selection included in systematic review: (n= 16) RCT: (n = 12) CCT: (n = 4)  Results: Brief Summary of Included Studies ¾  Patellar tendon N = 6 z  ¾  Achilles tendon N = 7 z  ¾  Age range: 22-31 years  Age range: 39-51 years  Wrist extensors N = 3 z  Age range: 38-47 years  Results: Heterogeneity of studies ¾  Eccentric Exercise (EE): variety of exercises z  ¾  Comparative Treatments (CT): z  ¾ ¾ ¾ ¾  some protocols have participants exercising through moderate amounts of pain Concentric exercise, night splint, stretches, shock wave therapy, TENS, US, DTFM, control  Duration of symptoms: 3-41 months Duration of Intervention: 4-24 weeks Number of participants: 15-124 persons Types of participants: z z z  Recreational athletes (4 studies) Competitive university volleyball players (5 studies) General population  Outcome Measurements ICF Classification Body function and structure: z  Pain and strength  Activity: z  Functional assessments and questionnaires such as: • • • • •  Victorian Institute of Sport Assessment (VISA) Foot and Ankle Outcome Score (FAOS) Pain free grip (PFG) The Disabilities of the Arm, Shoulder and Hand (DASH) Grip strength, global assessments, performance measurements  Participation: z  Quality of life questionnaires and return to sport  Included Studies 12 RCTs3,15-24 ¾ 7 studies rated as high quality (range 6-8) ¾ 5 studies rated as low quality (range 3-5) 4 CCTs25-28 ¾ 1study rated as high quality ( score 7) ¾ 3 studies rated as low quality (range 2-5)  Results ¾ Calculated  the Standard Mean Difference (SMD) between the EE intervention and the CT  * could only calculate SMD on 9 of 16 studies due to lack of data ¾ Applied  these findings to a best evidence synthesis model  Results: SMD achilles Tendon Author  Pain SMD  Design  Strength SMD  Functional Assessment SMD  Health related QoL SMD  ii) EE vs CT: 1.28  ii) 0.93  Achilles Tendinosis Alfredson et al. (1998)  CCT  Rompe et al. (2007)  RCT  Roos et al. (2004)  RCT  1.77  i) EE vs EE + splint: 0.47 ii) EE vs splint: 0.69  iii) 0.65  Results: SMD patellar tendon Author  Pain SMD  Design  Strength SMD  Functional Assessment SMD  Patellar Tendinosis Jonsson and Alfredson (2005)  RCT  1.98  Purdam et al. (2004)  CCT  1.79  2.44  Health related QoL SMD  Results: SMD wrist extensors Author  Pain SMD  Design  Strength SMD  Functional Assessment SMD  Health related QoL SMD  Wrist Extensor tendinosis Croisier et al. (2001)  CCT  2.39  ii) 1.02 iii) 2.14  1.04  Results: Best Evidence Synthesis Tool used to comment on the strength of the results based on: 1. Statistically significant findings from the calculation of the SMD 2. The study design ( RCTs or CCTs)  Best Evidence Synthesis Limited Evidence ¾Statistically  significant findings in outcome measures in at least one high quality RCT, OR ¾Consistent statistically significant findings in outcome measures in at least two high quality CCTs  Indicative Findings ¾Statistically  significant findings in outcome and/or process measures in at least one high quality CCT or low quality RCT  No Evidence ¾Results  of eligible studies do not meet the criteria for one of the above stated level of evidence, OR ¾In the case of conflicting results among RCTs and CCTs Table adapted from Steultjens et al. 2002  Results: Best Evidence Synthesis Achilles Limited evidence for the effectiveness of EE interventions on functional ability Limited evidence for the effectiveness of EE interventions on increasing health-related quality of life when compared to a “wait and see” control group No evidence to support the effectiveness of EE on decreasing pain or on increasing strength when compared to CT – due to conflicting findings  Results: Best Evidence Synthesis Patella Indicative findings for the effectiveness of EE interventions on pain outcomes over other CTs. Indicative findings for the effectiveness of EE interventions on functional ability versus CTs. No evidence was found for the effectiveness of EE interventions on strength when compared to CTs.  Results: Best Evidence Synthesis Wrist extensors Indicative findings that EE interventions are effective for improving the patient’s quality of life over other CTs. No evidence for the effectiveness of EE interventions on decreasing pain or increasing strength when compared against CTs (due to conflicting findings)  Discussion  General Limitations Study design z  z  z  z  z  Intervening variables: • EE with concentric component (2 studies) • Treatment & control treatment groups share co-treatments (4 studies) Poor control of intervention: • Monitoring adherence, controlling progression Underpowered: • 12/16 studies with sample populations < 50 • Inability to conduct meta-analysis or sub group analysis due to heterogeneity Lack of true controls • Use control treatments for comparison so does not examine absolute effectiveness of EE. Limits findings to effectiveness of EE versus alternative treatment. Outcome measures • Non-validated and non-standardized preventing comparisons & weakening findings  General Limitations ¾  Study Quality Shortcomings (van Tulder criteria13) z z z z  ¾  Reporting z  ¾  Description of randomization Concealment of treatment allocation Blinding outcome assessors Intention to treat analysis 7 out of 16 studies excluded from best evidence synthesis due to lack of data  Generalizability z  8 out of 16 studies use young, elite athletes  Eccentric Exercise: What is an optimal Protocol? ¾ ¾  Differences of opinion persist as to optimal exercise intervention 9 out of 16 studies use intervention based on Alfredson protocol (Alfredson 1998) 25 z z z z z z  2 x/day 7days/week 3 x 15 reps 12 week intervention Exercise with pain (VAS score varies) Progression with added weight  Eccentric Protocol ¾  Alfredson model is based on clinical experience and lacks a scientific basis29  ¾  Croisier et al. (2007) found good results in a well controlled study training subjects 3 x/ week versus 7 x/week ¾  They argue that an optimal prescription involves periods of rest to allow for recovery from post exercise weakness  Eccentric Protocol: How much pain? ¾  Alfredson et al. (1998) suggest that pain is an essential component of their successful intervention in AT  ¾  Curwin and Stanish (1984) achieve good results with a painless protocol in PT and LET3,17,28  ¾  For LET, researchers argue against training into pain claiming that it may have a negative impact on patient compliance and provoke injury21,28  Clinical Relevance Overall, the studies demonstrate a positive trend in favour of EE ¾ Clinicians must consider whether the subjects studied are representative of their patient population and whether the EE intervention is realistic, particularly when considering prescribed loads, frequency and intensity of pain with exercise ¾  Future Research Design ¾ Better  research design ¾ Consistent/validated Outcome Measures ¾ Larger samples z  Allow subgroup analysis to uncover the impacts of factors such as age, sex, activity, biomechanical faults, and duration or severity of symptoms  ¾ Post z  treatment assessments  To determine long-term impact  Future Research Topics ¾  ¾ ¾  Improve understanding of physiological effect of EE on the muscle tendon unit & whether this varies by tendon Optimal EE intervention Impact of intrinsic & extrinsic factors on occurrence of tendinosis z z  ¾  Intrinsic (e.g. age, gender, biomechanics, genetics) Extrinsic factors (e.g. environment, physical load, training errors)  Improved understanding of the pathophysiology of tendinosis across tendons  Conclusion ¾ This  review demonstrates a lack of well designed high quality studies providing limited evidence to support the clinical effectiveness of EE over other conservative treatments in the rehabilitation of tendinosis.  Acknowledgements  A great BIG Thanks to Dr. Linda Li and Charlotte Beck for their help with this project  Questions?  References 1. 2. 3.  4. 5. 6. 7. 8. 9. 10.  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