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Emerging enzyme surface display systems for waste resource recovery Davenport, Beth; Hallam, Steven James
Abstract
The current century marks an inflection point for human progress, as the developed world increasingly comes to recognize that the ecological and socioeconomic impacts of resource extraction must be balanced with more sustainable modes of growth that are less reliant on non-renewable sources of energy and materials. This has opened a window of opportunity for cross sector development of biotechnologies that harness the metabolic problem solving power of microbial communities. In this context, recovery has emerged as an organizing principal to create value from industrial and municipal waste streams, and the search is on for new enzymes and platforms that can be used for waste resource recovery at scale. Enzyme surface display on cells or functionalized materials has emerged as a promising platform for waste valorization. Typically, surface display involves the use of substrate binding or catalytic domains of interest translationally fused with extracellular membrane proteins in a microbial chassis. Novel display systems with improved performance features include S-layer display with increased protein density, spore display with increased resistance to harsh conditions, and intracellular inclusions including DNA-free cells or nanoparticles with improved social licence for in situ applications. Combining these display systems with advances in bioprinting, electrospinning and high-throughput functional screening have potential to transform outmoded extractive paradigms into ‘trans-metabolic” processes for remediation and waste resource recovery within an emerging circular bioeconomy.
Item Metadata
| Title |
Emerging enzyme surface display systems for waste resource recovery
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| Creator | |
| Contributor | |
| Date Issued |
2023-02
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| Description |
The current century marks an inflection point for human progress, as the
developed world increasingly comes to recognize that the ecological and
socioeconomic impacts of resource extraction must be balanced with more
sustainable modes of growth that are less reliant on non-renewable sources
of energy and materials. This has opened a window of opportunity for cross sector
development of biotechnologies that harness the metabolic problem solving
power of microbial communities. In this context, recovery has
emerged as an organizing principal to create value from industrial and
municipal waste streams, and the search is on for new enzymes and platforms
that can be used for waste resource recovery at scale. Enzyme surface
display on cells or functionalized materials has emerged as a
promising platform for waste valorization. Typically, surface display involves
the use of substrate binding or catalytic domains of interest translationally
fused with extracellular membrane proteins in a microbial chassis. Novel
display systems with improved performance features include S-layer display
with increased protein density, spore display with increased resistance to
harsh conditions, and intracellular inclusions including DNA-free cells or
nanoparticles with improved social licence for in situ applications. Combining
these display systems with advances in bioprinting, electrospinning and
high-throughput functional screening have potential to transform outmoded
extractive paradigms into ‘trans-metabolic” processes for remediation and
waste resource recovery within an emerging circular bioeconomy.
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| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2025-06-25
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0449207
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| URI | |
| Affiliation | |
| Citation |
Davenport B, Hallam SJ. Emerging enzyme surface display systems for waste resource recovery. Environ Microbiol. 2023 Feb;25(2):241-249.
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| Publisher DOI |
10.1111/1462-2920.16284
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International