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A small clinical trial of vaporized cannabis for PTSD : suggestive results and directions for future study Walsh, Zach; Mitchell, Ian; Crosby, Kim; St. Pierre, Michelle; DeClerck, Drew; Ong, Kaye; Lucas, Philippe

Description

The last few decades have seen increasing interest in the use of cannabis for post-traumatic stress disorder (PTSD). Recent attempts to evaluate the clinical efficacy of cannabis for PTSD were inconclusive and generalizability was limited by undesirable features of the study drug. The present clinical trial evaluated the effects of a commercially available chemovar that was delivered by vaporization. The study was designed as a randomized placebo-controlled cross-over study with three conditions; however, only five individuals completed the trial, and analysis of the placebo effect was not possible. Results identified positive changes consistent with medium-sized within-subject effects for cannabis in the treatment of PTSD. Positive trending results and high patient need mandate future studies of cannabis for the treatment of PTSD.

Item Metadata

Title
A small clinical trial of vaporized cannabis for PTSD : suggestive results and directions for future study
Creator
Walsh, Zach; Mitchell, Ian; Crosby, Kim; St. Pierre, Michelle; DeClerck, Drew; Ong, Kaye; Lucas, Philippe
Contributor
BC Cancer Agency
Publisher
BioMed Central
Date Issued
2023-09-09
Description
The last few decades have seen increasing interest in the use of cannabis for post-traumatic stress disorder (PTSD). Recent attempts to evaluate the clinical efficacy of cannabis for PTSD were inconclusive and generalizability was limited by undesirable features of the study drug. The present clinical trial evaluated the effects of a commercially available chemovar that was delivered by vaporization. The study was designed as a randomized placebo-controlled cross-over study with three conditions; however, only five individuals completed the trial, and analysis of the placebo effect was not possible. Results identified positive changes consistent with medium-sized within-subject effects for cannabis in the treatment of PTSD. Positive trending results and high patient need mandate future studies of cannabis for the treatment of PTSD.
Subject
Medical cannabis; PTSD; Plant medicine
Type
Text
Language
eng
Date Available
2023-11-15
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0437687
URI
http://hdl.handle.net/2429/86528
Affiliation
Arts and Social Sciences, Irving K. Barber Faculty of (Okanagan); Medicine, Faculty of; Non UBC; Emergency Medicine, Department of; Psychology, Department of (Okanagan)
Citation
Trials. 2023 Sep 09;24(1):578
Publisher DOI
10.1186/s13063-023-07543-2
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Graduate
Copyright Holder
BioMed Central Ltd., part of Springer Nature
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Rights

Attribution 4.0 International (CC BY 4.0)