- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Faculty Research and Publications /
- Simple clinical pharmacology can improve prescribing
Open Collections
UBC Faculty Research and Publications
Simple clinical pharmacology can improve prescribing Therapeutics Initiative (University of British Columbia)
Description
Therapeutics Letter 142 explores pharmacokinetics principles that can help clinicians prescribe efficiently and avoid common problems. Conclusions: Knowing Tmax can suggest when to assess symptomatic effects of a drug (good or bad). Allowing 4 to 5 half-lives predicts steady state effects of drugs taken for symptoms. When a drug is stopped, expect effects to dissipate or potential withdrawal symptoms to emerge after a similar interval. Some half-lives reported as means have significant inter-individual ranges. Patients who report shorter or longer duration of effects than expected may have different elimination kinetics. “Steady state” seldom applies in sick people. Acute decline in kidney function or saturated liver metabolism can cause dangerous toxicity: e.g., K+, lithium, gabapentin, pregabalin, acetaminophen, phenytoin, alcohol.
Item Metadata
Title |
Simple clinical pharmacology can improve prescribing
|
Alternate Title |
Therapeutics Letter 142
|
Creator | |
Date Issued |
2023-04
|
Description |
Therapeutics Letter 142 explores pharmacokinetics principles that can help clinicians prescribe efficiently and avoid common problems. Conclusions: Knowing Tmax can suggest when to assess symptomatic effects of a drug (good or bad). Allowing 4 to 5 half-lives predicts steady state effects of drugs taken for symptoms. When a drug is stopped, expect effects to dissipate or potential withdrawal symptoms to emerge after a similar interval. Some half-lives reported as means have significant inter-individual ranges. Patients who report shorter or longer duration of effects than expected may have different elimination kinetics. “Steady state” seldom applies in sick people. Acute decline in kidney function or saturated liver metabolism can cause dangerous toxicity: e.g., K+, lithium, gabapentin, pregabalin, acetaminophen, phenytoin, alcohol.
|
Subject | |
Genre | |
Type | |
Language |
eng
|
Notes |
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
|
Date Available |
2023-06-20
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
DOI |
10.14288/1.0433716
|
URI | |
Affiliation | |
Peer Review Status |
Reviewed
|
Scholarly Level |
Faculty; Researcher
|
Rights URI | |
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International