UBC Faculty Research and Publications

Primary hypertension therapy : after thiazide, an ACEI or an ARB? University of British Columbia. Therapeutics Initiative


Therapeutics Letter 133 evaluates optimal treatments for primary hypertension using Cochrane systematic review evidence. Conclusions: Low-dose thiazides are the best drug class for starting antihypertensive therapy. ACEIs are the preferred second line treatment. Antihypertensives achieve most of their BP lowering effect at starting or low doses. Reserve ARBs for patients with ACEI cough or angioedema.

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