Tramadol : Where do we go from here? University of British Columbia. Therapeutics Initiative
Therapeutics Letter 131 considers the harms and potential benefits of tramadol. Conclusions: Compared with acetaminophen, NSAIDs or other opioids, tramadol has no therapeutic advantage but some disadvantages. Tramadol’s unpredictable metabolism and complex pharmacology are associated with unique and serious adverse effects. As with other opioids, even short prescriptions for tramadol can engender tolerance, dependence, withdrawal, and abuse. Tramadol (+/- acetaminophen) significantly increases costs to patients and insurers.
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