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Mirtazapine : Update on efficacy, safety, dose response Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 129 provides an update on the efficacy, safety and dose response for mirtazapine. Conclusions Mirtazapine’s efficacy for depression is similar to other commonly-prescribed antidepressants. It causes drowsiness, weight gain, and dry mouth. Doses above 30 mg daily provide fewer benefits but markedly increase harms. Prescribing mirtazapine for insomnia has not been validated by clinical trials. Adding mirtazapine to an SSRI or SNRI does not improve efficacy but increases harm.

Item Metadata

Title
Mirtazapine : Update on efficacy, safety, dose response
Alternate Title
Therapeutics Letter 129
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2021-02
Description
Therapeutics Letter 129 provides an update on the efficacy, safety and dose response for mirtazapine. Conclusions Mirtazapine’s efficacy for depression is similar to other commonly-prescribed antidepressants. It causes drowsiness, weight gain, and dry mouth. Doses above 30 mg daily provide fewer benefits but markedly increase harms. Prescribing mirtazapine for insomnia has not been validated by clinical trials. Adding mirtazapine to an SSRI or SNRI does not improve efficacy but increases harm.
Subject
Antidepressive Agents; Depression; Mirtazapine; Serotonin and Noradrenaline Reuptake Inhibitors; Sleepiness; Sleep Initiation and Maintenance Disorders
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433708
URI
http://hdl.handle.net/2429/85118
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International