Serious harms with long-term PPI use in older adults University of British Columbia. Therapeutics Initiative
Therapeutics Letter 126 considers serious harms with long-term proton pump inhibitor use in older adults. Conclusions: Observational studies have identified signals of serious harms from long-term PPI exposure, including an increased risk of death. Even large RCTs may not detect these, if exposure or follow-up are insufficiently long. The COMPASS trial findings are not inconsistent with contemporaneous findings from observational studies. Clinicians and patients can reverse the relentless expansion of long-term PPI exposure by reviewing indications and considering potential harms as well as benefits.
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