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Serious harms with long-term PPI use in older adults Therapeutics Initiative (University of British Columbia)
Description
Therapeutics Letter 126 considers serious harms with long-term proton pump inhibitor use in older adults. Conclusions: Observational studies have identified signals of serious harms from long-term PPI exposure, including an increased risk of death. Even large RCTs may not detect these, if exposure or follow-up are insufficiently long. The COMPASS trial findings are not inconsistent with contemporaneous findings from observational studies. Clinicians and patients can reverse the relentless expansion of long-term PPI exposure by reviewing indications and considering potential harms as well as benefits.
Item Metadata
Title |
Serious harms with long-term PPI use in older adults
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Alternate Title |
Therapeutics Letter 126
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Creator | |
Date Issued |
2020-04
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Description |
Therapeutics Letter 126 considers serious harms with long-term proton pump inhibitor use in older adults. Conclusions: Observational studies have identified signals of serious harms from long-term PPI exposure, including an increased risk of death. Even large RCTs may not detect these, if exposure or follow-up are insufficiently long. The COMPASS trial findings are not inconsistent with contemporaneous findings from observational studies. Clinicians and patients can reverse the relentless expansion of long-term PPI exposure by reviewing indications and considering potential harms as well as benefits.
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Subject | |
Genre | |
Type | |
Language |
eng
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Notes |
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
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Date Available |
2023-06-20
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0433705
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URI | |
Affiliation | |
Peer Review Status |
Reviewed
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Scholarly Level |
Faculty; Researcher
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International