Gabapentin and pregabalin : Are high doses justified? University of British Columbia. Therapeutics Initiative
Therapeutics Letter 117 questions the use of high doses of gabapentin and pregabalin for pain. Conclusions: Many British Columbians receive very high doses, against best evidence. Most patients will not benefit from gabapentin or pregabalin for pain. Do not expect better pain relief from high doses. At any dose, assess for benefit or harm within 1-2 weeks; reassess often for dose reduction or deprescribing. Adverse effects increase at higher doses. Expect more harms in frailty, impaired kidney function, or in patients using other sedative drugs or alcohol.
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