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Gabapentin and pregabalin : Are high doses justified? University of British Columbia. Therapeutics Initiative

Description

Therapeutics Letter 117 questions the use of high doses of gabapentin and pregabalin for pain. Conclusions: Many British Columbians receive very high doses, against best evidence. Most patients will not benefit from gabapentin or pregabalin for pain. Do not expect better pain relief from high doses. At any dose, assess for benefit or harm within 1-2 weeks; reassess often for dose reduction or deprescribing. Adverse effects increase at higher doses. Expect more harms in frailty, impaired kidney function, or in patients using other sedative drugs or alcohol.

Item Metadata

Title
Gabapentin and pregabalin : Are high doses justified?
Alternate Title
Therapeutics Letter 117
Creator
University of British Columbia. Therapeutics Initiative
Date Issued
2019-01
Description
Therapeutics Letter 117 questions the use of high doses of gabapentin and pregabalin for pain. Conclusions: Many British Columbians receive very high doses, against best evidence. Most patients will not benefit from gabapentin or pregabalin for pain. Do not expect better pain relief from high doses. At any dose, assess for benefit or harm within 1-2 weeks; reassess often for dose reduction or deprescribing. Adverse effects increase at higher doses. Expect more harms in frailty, impaired kidney function, or in patients using other sedative drugs or alcohol.
Subject
Deprescriptions; Drug-Related Side Effects and Adverse Reactions; Gabapentin; Hypnotics and Sedatives; Pain; Pregabalin
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433696
URI
http://hdl.handle.net/2429/85106
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
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Attribution-NonCommercial-NoDerivatives 4.0 International