Shingrix : A New Vaccine for Shingles

UBC Faculty Research and Publications

Shingrix : A New Vaccine for Shingles Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 114 looks at Shingrix, a new vaccine for shingles. Conclusions: Compared to placebo the Shingrix vaccine reduced the incidence of herpes zoster by 3.26 % (NNV = 31) over 3.5 years in all age groups and reduced the incidence of post-herpetic neuralgia by 0.28% (NNV ≈ 350). Compared to placebo Shingrix increased grade 3 systemic reactions (which prevented normal daily activities for about 1-3 days) by 4 to 9% (NNH 11 to 25). The effectiveness (i.e. maintained protection) and safety of Shingrix are still unknown beyond about four years. Discuss the balance of baseline herpes zoster risk, harms, benefits and costs when considering this vaccine.

Item Metadata

Title	Shingrix : A New Vaccine for Shingles
Alternate Title	Therapeutics Letter 114
Creator	Therapeutics Initiative (University of British Columbia)
Date Issued	2018-10
Description	Therapeutics Letter 114 looks at Shingrix, a new vaccine for shingles. Conclusions: Compared to placebo the Shingrix vaccine reduced the incidence of herpes zoster by 3.26 % (NNV = 31) over 3.5 years in all age groups and reduced the incidence of post-herpetic neuralgia by 0.28% (NNV ≈ 350). Compared to placebo Shingrix increased grade 3 systemic reactions (which prevented normal daily activities for about 1-3 days) by 4 to 9% (NNH 11 to 25). The effectiveness (i.e. maintained protection) and safety of Shingrix are still unknown beyond about four years. Discuss the balance of baseline herpes zoster risk, harms, benefits and costs when considering this vaccine.
Subject	Herpes Zoster; Herpes Zoster Vaccine; Vaccination
Genre	Other
Type	Text
Language	eng
Notes	The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available	2023-06-20
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0433693
URI	http://hdl.handle.net/2429/85103
Affiliation	Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status	Reviewed
Scholarly Level	Faculty; Researcher
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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