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Questioning the basis of approval for non-insulin glucose lowering drugs Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 100 considers the basis for the approval of non-insulin glucose lowering drugs. Conclusions: Widely prescribed glucose lowering drugs for people with type 2 diabetes have been approved in Canada without evidence that they reduce mortality or major morbidity. The best available evidence does not support Health Canada’s assertion that intensive glucose lowering in persons with type 2 diabetes “will contribute to the safety of subjects”. The current regulatory framework for glucose lowering drugs that bases benefit on lowering HbA1c and bases harms on not increasing specific cardiovascular outcomes requires rethinking.

Item Metadata

Title
Questioning the basis of approval for non-insulin glucose lowering drugs
Alternate Title
Therapeutics Letter 100
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2016-06
Description
Therapeutics Letter 100 considers the basis for the approval of non-insulin glucose lowering drugs. Conclusions: Widely prescribed glucose lowering drugs for people with type 2 diabetes have been approved in Canada without evidence that they reduce mortality or major morbidity. The best available evidence does not support Health Canada’s assertion that intensive glucose lowering in persons with type 2 diabetes “will contribute to the safety of subjects”. The current regulatory framework for glucose lowering drugs that bases benefit on lowering HbA1c and bases harms on not increasing specific cardiovascular outcomes requires rethinking.
Subject
Hypoglycemic Agents; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Morbidity
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433679
URI
http://hdl.handle.net/2429/85089
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
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Attribution-NonCommercial-NoDerivatives 4.0 International