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Comparative effectiveness of proton pump inhibitors Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 99 reviews the comparative effectiveness of proton pump inhibitors. Conclusions: There is currently no convincing RCT evidence that one PPI is preferable to another for the management of GERD or PUD related symptoms or for endoscopically confirmed healing of esophagitis. The risk of bias assessment of the 63 included RCTs indicated a high risk of selection, reporting, performance and detection bias. There are no long-term, head-to-head comparative RCTs specifically designed to monitor adverse effects of PPIs. Observational studies suggest that long-term use of PPIs is associated with a number of serious adverse effects. The cost of different PPIs vary by over tenfold.

Item Metadata

Title
Comparative effectiveness of proton pump inhibitors
Alternate Title
Therapeutics Letter 99
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2016-04
Description
Therapeutics Letter 99 reviews the comparative effectiveness of proton pump inhibitors. Conclusions: There is currently no convincing RCT evidence that one PPI is preferable to another for the management of GERD or PUD related symptoms or for endoscopically confirmed healing of esophagitis. The risk of bias assessment of the 63 included RCTs indicated a high risk of selection, reporting, performance and detection bias. There are no long-term, head-to-head comparative RCTs specifically designed to monitor adverse effects of PPIs. Observational studies suggest that long-term use of PPIs is associated with a number of serious adverse effects. The cost of different PPIs vary by over tenfold.
Subject
Drug-Related Side Effects and Adverse Reactions; Esophagitis; Gastroesophageal Reflux; Iatrogenic Disease; Peptic Ulcer; Proton Pump Inhibitors
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433678
URI
http://hdl.handle.net/2429/85088
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
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Attribution-NonCommercial-NoDerivatives 4.0 International