The limitations and potential hazards of using surrogate markers

UBC Faculty Research and Publications

The limitations and potential hazards of using surrogate markers Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 92 explores the limitations and potential hazards of using surrogate markers. Conclusions: Most commonly used surrogate markers have not been proven to be consistently predictive of morbidity or mortality risk thus their use in risk calculators is questionable. Relying on surrogate markers to assess effectiveness of drug therapy has not been proven to yield clinically meaningful benefits and there are important examples where that strategy was harmful. Avoid chasing surrogate targets (e.g. LDL-C targets) that have not been proven to have a net health benefit.

Item Metadata

Title	The limitations and potential hazards of using surrogate markers
Alternate Title	Therapeutics Letter 92
Creator	Therapeutics Initiative (University of British Columbia)
Date Issued	2014-12
Description	Therapeutics Letter 92 explores the limitations and potential hazards of using surrogate markers. Conclusions: Most commonly used surrogate markers have not been proven to be consistently predictive of morbidity or mortality risk thus their use in risk calculators is questionable. Relying on surrogate markers to assess effectiveness of drug therapy has not been proven to yield clinically meaningful benefits and there are important examples where that strategy was harmful. Avoid chasing surrogate targets (e.g. LDL-C targets) that have not been proven to have a net health benefit.
Subject	Biomarkers; Drug Safety; Morbidity; Mortality
Genre	Other
Type	Text
Language	eng
Notes	The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available	2023-06-20
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0433671
URI	http://hdl.handle.net/2429/85081
Affiliation	Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status	Reviewed
Scholarly Level	Faculty; Researcher
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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