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A Systematic Review of the Harms of Bisphosphonates Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 84 reviews the evidence for harms associated with long-term use of alendronate, etidronate, and risedronate. Conclusions: Systematic reviews assessing harms using observational studies are more difficult to conduct than traditional systematic reviews of RCTs assessing benefits. Bisphosphonates are associated with serious harms that are of similar clinical significance to their benefits. In secondary prevention, the small benefits of bisphosphonates likely outweigh the harms during the first 3 years of therapy, but harms likely outweigh benefits for durations greater than 3 years.

Item Metadata

Title
A Systematic Review of the Harms of Bisphosphonates
Alternate Title
Therapeutics Letter 84
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2011-12
Description
Therapeutics Letter 84 reviews the evidence for harms associated with long-term use of alendronate, etidronate, and risedronate. Conclusions: Systematic reviews assessing harms using observational studies are more difficult to conduct than traditional systematic reviews of RCTs assessing benefits. Bisphosphonates are associated with serious harms that are of similar clinical significance to their benefits. In secondary prevention, the small benefits of bisphosphonates likely outweigh the harms during the first 3 years of therapy, but harms likely outweigh benefits for durations greater than 3 years.
Subject
Aledronate; Diphosphonates; Etidronic Acid; Risedronic Acid; Secondary Prevention
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433663
URI
http://hdl.handle.net/2429/85073
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International