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A Systematic Review of the Efficacy of Bisphosphonates Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 83 reports the findings of our systematic review of the randomized controlled trial evidence of the benefits and harms of bisphosphonates. Conclusions: There are no proven clinically meaningful benefits for bisphosphonates in postmenopausal women without a prior fracture or vertebral compression. Because of the small magnitude of effect and the high risk of bias in the RCTs, it is unclear whether bisphosphonates cause a clinically meaningful reduction of hip fractures in women with a prior fracture or vertebral compression. For any new class of drugs indicated to prevent bone fractures, it is essential that a clinically meaningful reduction in hip fractures be demonstrated before licensing.

Item Metadata

Title
A Systematic Review of the Efficacy of Bisphosphonates
Alternate Title
Therapeutics Letter 83
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2011-10
Description
Therapeutics Letter 83 reports the findings of our systematic review of the randomized controlled trial evidence of the benefits and harms of bisphosphonates. Conclusions: There are no proven clinically meaningful benefits for bisphosphonates in postmenopausal women without a prior fracture or vertebral compression. Because of the small magnitude of effect and the high risk of bias in the RCTs, it is unclear whether bisphosphonates cause a clinically meaningful reduction of hip fractures in women with a prior fracture or vertebral compression. For any new class of drugs indicated to prevent bone fractures, it is essential that a clinically meaningful reduction in hip fractures be demonstrated before licensing.
Subject
Diphosphonates; Drug-Related Side Effects and Adverse Reactions; Fractures, Compression; Postmenopause
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433662
URI
http://hdl.handle.net/2429/85072
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International