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Is use of quetiapine for sleep evidence-based? Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 79 examines efficacy and safety evidence about use of low dose quetiapine for sleep disorders. Conclusions: Quetiapine is not approved nor recommended for primary insomnia. Quetiapine is commonly prescribed off-label as a sleep aid, but only one RCT examined its use in patients with insomnia. It found no benefit. No published RCT evidence exists comparing quetiapine with other drugs for insomnia. Management of primary insomnia should focus on education and encouragement of appropriate sleep habits. Drugs should be limited to short duration, intermittent use, or daily use only in exceptional cases.

Item Metadata

Title
Is use of quetiapine for sleep evidence-based?
Alternate Title
Therapeutics Letter 79
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2010-12
Description
Therapeutics Letter 79 examines efficacy and safety evidence about use of low dose quetiapine for sleep disorders. Conclusions: Quetiapine is not approved nor recommended for primary insomnia. Quetiapine is commonly prescribed off-label as a sleep aid, but only one RCT examined its use in patients with insomnia. It found no benefit. No published RCT evidence exists comparing quetiapine with other drugs for insomnia. Management of primary insomnia should focus on education and encouragement of appropriate sleep habits. Drugs should be limited to short duration, intermittent use, or daily use only in exceptional cases.
Subject
Off-Label Use; Quetiapine Fumarate; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433658
URI
http://hdl.handle.net/2429/85068
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International