Open Collections

UBC Faculty Research and Publications

Treatment of elevated blood pressure in the very elderly : Less is better Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 71 focusses on the best available evidence about drug treatment of elevated blood pressure in individuals over 79 years of age. Conclusions: For patients ≥80 years: Various antihypertensive therapies for primary prevention in relatively healthy patients with systolic BP >160 mmHg reduced stroke, but had no proven effect on mortality. Using low-dose thiazide as first-line therapy followed by a low-medium dose ACE inhibitor reduced mortality as well as serious adverse events in one large RCT. With this regimen a blood pressure of <150/80 mmHg can be expected in about 50% of patients.

Item Metadata

Title
Treatment of elevated blood pressure in the very elderly : Less is better
Alternate Title
Therapeutics Letter 71
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2008-10
Description
Therapeutics Letter 71 focusses on the best available evidence about drug treatment of elevated blood pressure in individuals over 79 years of age. Conclusions: For patients ≥80 years: Various antihypertensive therapies for primary prevention in relatively healthy patients with systolic BP >160 mmHg reduced stroke, but had no proven effect on mortality. Using low-dose thiazide as first-line therapy followed by a low-medium dose ACE inhibitor reduced mortality as well as serious adverse events in one large RCT. With this regimen a blood pressure of <150/80 mmHg can be expected in about 50% of patients.
Subject
Aged; Antihypertensive Agents; Drug Costs; Hypertension; Patient Safety; Thiazides
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433650
URI
http://hdl.handle.net/2429/85060
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International