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Rofecoxib (Vioxx®) withdrawal generates uncertainty about “COX-2s” : Do product monographs adequately inform? Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 53 considers whether the Product Monographs for rofecoxib and the other non-steroidal anti-inflammatory drugs marketed as COX-2 selective NSAID’s adequately inform clinicians about the benefits and harms of these drugs. Conclusions: Product monographs sometimes provide data about drug harms including serious adverse events that is not published elsewhere; represent a challenge in finding, extracting and interpreting the relevant information; do not adequately inform clinicians. Celecoxib, meloxicam and valdecoxib 2004 monographs do not claim to improve arthritis symptoms better than non-selective NSAIDs; do not warn against prescribing to patients with a history of peptic ulcer disease; do not claim to reduce complicated ulcers as compared with non-selective NSAIDs; provide insufficient information as to whether or not these drugs increase myocardial infarction or total cardiovascular thrombotic events.

Item Metadata

Title
Rofecoxib (Vioxx®) withdrawal generates uncertainty about “COX-2s” : Do product monographs adequately inform?
Alternate Title
Therapeutics Letter 53
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2004-10
Description
Therapeutics Letter 53 considers whether the Product Monographs for rofecoxib and the other non-steroidal anti-inflammatory drugs marketed as COX-2 selective NSAID’s adequately inform clinicians about the benefits and harms of these drugs. Conclusions: Product monographs sometimes provide data about drug harms including serious adverse events that is not published elsewhere; represent a challenge in finding, extracting and interpreting the relevant information; do not adequately inform clinicians. Celecoxib, meloxicam and valdecoxib 2004 monographs do not claim to improve arthritis symptoms better than non-selective NSAIDs; do not warn against prescribing to patients with a history of peptic ulcer disease; do not claim to reduce complicated ulcers as compared with non-selective NSAIDs; provide insufficient information as to whether or not these drugs increase myocardial infarction or total cardiovascular thrombotic events.
Subject
Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Documentation; Meloxicam; Peptic Ulcer; Rofecoxib; Valdecoxib
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433632
URI
http://hdl.handle.net/2429/85042
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International