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COX-2 inhibitors update : Do journal publications tell the full story? Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 43 provides an update on COX-2 inhibitors. Conclusions: Based on FDA data from the CLASS and VIGOR studies, COX-2 selective inhibitors are associated with an increased incidence of serious adverse events as compared to non-selective NSAIDs. Published versions of the CLASS and VIGOR trials focused on GI events and failed to report other serious adverse events fully. In the interests of public safety, serious adverse event rates from all trials must be published.

Item Metadata

Title
COX-2 inhibitors update : Do journal publications tell the full story?
Alternate Title
Therapeutics Letter 43
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2002-01
Description
Therapeutics Letter 43 provides an update on COX-2 inhibitors. Conclusions: Based on FDA data from the CLASS and VIGOR studies, COX-2 selective inhibitors are associated with an increased incidence of serious adverse events as compared to non-selective NSAIDs. Published versions of the CLASS and VIGOR trials focused on GI events and failed to report other serious adverse events fully. In the interests of public safety, serious adverse event rates from all trials must be published.
Subject
Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Drug-Related Side Effects and Adverse Reactions
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433622
URI
http://hdl.handle.net/2429/85032
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International