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Serious Adverse Event Analysis : Lipid-Lowering Therapy Revisited Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 42 explores the reporting of serious adverse events (SAEs) using examples from lipid-lowering trials. Conclusions: Total %SAEs is an important measure of the health impact of a drug. Total %SAEs is often not reported in published RCTs, including lipid-lowering trials. Mortality analysis supports the use of statins for secondary prevention. Analysis of SAEs and mortality does not support the use of statins for primary prevention or the use of fibrates for primary or secondary prevention.

Item Metadata

Title
Serious Adverse Event Analysis : Lipid-Lowering Therapy Revisited
Alternate Title
Therapeutics Letter 42
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2001-10
Description
Therapeutics Letter 42 explores the reporting of serious adverse events (SAEs) using examples from lipid-lowering trials. Conclusions: Total %SAEs is an important measure of the health impact of a drug. Total %SAEs is often not reported in published RCTs, including lipid-lowering trials. Mortality analysis supports the use of statins for secondary prevention. Analysis of SAEs and mortality does not support the use of statins for primary prevention or the use of fibrates for primary or secondary prevention.
Subject
Drug-Related Side Effects and Adverse Reactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Secondary Prevention
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433621
URI
http://hdl.handle.net/2429/85031
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International