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What to do about borderline hyperglycemia? University of British Columbia. Therapeutics Initiative
Description
Background: Therapeutics Letter 140 discusses the issue of borderline hyperglycemia, a condition where blood sugar levels are slightly elevated but not high enough to be diagnosed as diabetes. This condition is becoming increasingly common and is associated with a higher risk of developing diabetes, cardiovascular disease, and other health problems. Methods: Current research on the management of borderline hyperglycemia was reviewed, including lifestyle interventions such as diet and exercise, as well as pharmacological interventions. The limitations of current diagnostic criteria for diabetes and the need for more accurate methods of identifying individuals at risk for the disease were also discussed. Results: The authors concluded that lifestyle interventions are the first-line treatment for individuals with borderline hyperglycemia, and that pharmacological interventions should be reserved for those who are at higher risk of developing diabetes or who have other risk factors. Available evidence suggests large RCTs combining lifestyle interventions with newer drugs such as GLP-1 agonists and SGLT2 inhibitors could potentially identify more promising treatments. Conclusions: Many people with borderline hyperglycemia will not progress to type 2 diabetes. Borderline hyperglycemia is associated with adverse health outcomes, but other risk factors for cardiovascular disease may be more important. Borderline hyperglycemia can be used as a “wake up call”: an opportunity to discuss options. Emphasize lifestyle optimization with improved diet and physical activity.
Item Metadata
Title |
What to do about borderline hyperglycemia?
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Alternate Title |
Therapeutics Letter 140
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Creator | |
Date Issued |
2022-12
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Description |
Background: Therapeutics Letter 140 discusses the issue of borderline hyperglycemia, a condition where blood sugar levels are slightly elevated but not high enough to be diagnosed as diabetes. This condition is becoming increasingly common and is associated with a higher risk of developing diabetes, cardiovascular disease, and other health problems. Methods: Current research on the management of borderline hyperglycemia was reviewed, including lifestyle interventions such as diet and exercise, as well as pharmacological interventions. The limitations of current diagnostic criteria for diabetes and the need for more accurate methods of identifying individuals at risk for the disease were also discussed. Results: The authors concluded that lifestyle interventions are the first-line treatment for individuals with borderline hyperglycemia, and that pharmacological interventions should be reserved for those who are at higher risk of developing diabetes or who have other risk factors. Available evidence suggests large RCTs combining lifestyle interventions with newer drugs such as GLP-1 agonists and SGLT2 inhibitors could potentially identify more promising treatments. Conclusions: Many people with borderline hyperglycemia will not progress to type 2 diabetes. Borderline hyperglycemia is associated with adverse health outcomes, but other risk factors for cardiovascular disease may be more important. Borderline hyperglycemia can be used as a “wake up call”: an opportunity to discuss options. Emphasize lifestyle optimization with improved diet and physical activity.
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Type | |
Language |
eng
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Notes |
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
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Date Available |
2023-06-01
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0432787
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URI | |
Affiliation | |
Peer Review Status |
Reviewed
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Scholarly Level |
Faculty; Researcher
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International