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Empiric Antibiotic Therapy for Uncomplicated Lower Urinary Tract Infections Therapeutics Initiative (University of British Columbia)

Description

Background: Therapeutics Letter 135 discusses antimicrobial best practices for treating uncomplicated UTIs in British Columbia (BC), Canada. Uncomplicated lower urinary tract infections (UTIs) are common and can be treated with empiric antibiotic therapy. However, antibiotic use should take into account local patterns of bacterial resistance. Conclusions: Urine dipstick/urinalysis and/or urine cultures are not recommended for diagnosing most uncomplicated lower urinary tract infections. Empiric prescription of nitrofurantoin for 5 to 7 days is recommended. The British Columbia Centre for Disease Control recommends one oral dose of fosfomycin 3 g when CrCl is ≤ 30mL/min or when there is allergy/intolerance to nitrofurantoin. TMP-SMX, fluoroquinolones, and beta-lactams are unsuitable for empiric therapy in BC due to bacterial resistance.

Item Metadata

Title
Empiric Antibiotic Therapy for Uncomplicated Lower Urinary Tract Infections
Alternate Title
Therapeutics Letter 135
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2022-03
Description
Background: Therapeutics Letter 135 discusses antimicrobial best practices for treating uncomplicated UTIs in British Columbia (BC), Canada. Uncomplicated lower urinary tract infections (UTIs) are common and can be treated with empiric antibiotic therapy. However, antibiotic use should take into account local patterns of bacterial resistance. Conclusions: Urine dipstick/urinalysis and/or urine cultures are not recommended for diagnosing most uncomplicated lower urinary tract infections. Empiric prescription of nitrofurantoin for 5 to 7 days is recommended. The British Columbia Centre for Disease Control recommends one oral dose of fosfomycin 3 g when CrCl is ≤ 30mL/min or when there is allergy/intolerance to nitrofurantoin. TMP-SMX, fluoroquinolones, and beta-lactams are unsuitable for empiric therapy in BC due to bacterial resistance.
Subject
Anti-Bacterial Agents; Drug Resistance, Microbial; Nitrofurantoin; Urinalysis; Urinary Tract Infections
Geographic Location
British Columbia
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-05-31
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0432743
URI
http://hdl.handle.net/2429/84720
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International