- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Faculty Research and Publications /
- The PIUO Pathway : A systematic approach to managing...
Open Collections
UBC Faculty Research and Publications
The PIUO Pathway : A systematic approach to managing pain and irritability in children with severe neurological impairment Ketchum, K.; Hermansen, Anne-Mette; Andrews, Gail; Pawliuk, Colleen; Dewan, T.; Gnanakumar, V.; Orkin, J.; Richardson, A.; Vadeboncoeur, C.; Holsti, Liisa; Carleton, Bruce C.; Oberlander, Tim F.; Siden, Harold
Description
Our goal at the Siden Lab is to improve the assessment and treatment of pain and irritability in children with complex health conditions and multiple disabilities who have limited communication and cognition. The origins of this discomfort are complex and poorly understood, so we use the term Pain and Irritability of Unknown Origin (PIUO) to describe them. We believe that lack of a standardized approach to investigating PIUO may be contributing to pain persistence in the kids we see. To address this, our team developed a systematic approach to investigating PIUO, which we call the PIUO Pathway. The goal of the PIUO Pathway is to efficiently identify treatable causes of pain and irritability. We are currently testing the efficacy of the PIUO Pathway. Participants are children who have a severe neurological impairment (SNI), extremely limited communication and mobility function, and are experiencing PIUO. We start by asking questions about the child’s health status, previous investigations and treatments. We also ask about the impact of the child’s PIUO on the family’s quality of life. Children are randomly assigned to the Pathway or Waitlist arms of the trial, and we work with the families to identify or exclude any sources of pain and irritability through structured history taking, physical examination, laboratory investigations and pharmacological interventions. We cannot always identify the source of pain using the PIUO Pathway. Moreover, in children with complex neurological conditions, pain and irritability are not always due to disease or injury, but instead may be due to generalized irritability of the central nervous system. Kids that are still experiencing PIUO after going through the Pathway are eligible to participate in our drug trial, which investigates the efficacy of gabapentin in relieving PIUO. Gabapentin was originally used as an antiseizure medication, but has since become more known as an effective treatment for chronic, complex pain. We hope that gabapentin can be proven to be beneficial in relieving these kids’ pain, the nature of which we still do not fully understand.
Item Metadata
| Title |
The PIUO Pathway : A systematic approach to managing pain and irritability in children with severe neurological impairment
|
| Alternate Title |
Pain Detectives : Optimizing the management of pain and irritability in children with severe neurological impairment
|
| Creator | |
| Contributor | |
| Date Issued |
2021
|
| Description |
Our goal at the Siden Lab is to improve the assessment and treatment of pain and irritability in
children with complex health conditions and multiple disabilities who have limited communication
and cognition. The origins of this discomfort are complex and poorly understood, so we use the term
Pain and Irritability of Unknown Origin (PIUO) to describe them. We believe that lack of a
standardized approach to investigating PIUO may be contributing to pain persistence in the kids we
see. To address this, our team developed a systematic approach to investigating PIUO, which we
call the PIUO Pathway. The goal of the PIUO Pathway is to efficiently identify treatable causes of
pain and irritability.
We are currently testing the efficacy of the PIUO Pathway. Participants are children who have a
severe neurological impairment (SNI), extremely limited communication and mobility function, and
are experiencing PIUO. We start by asking questions about the child’s health status, previous
investigations and treatments. We also ask about the impact of the child’s PIUO on the family’s
quality of life. Children are randomly assigned to the Pathway or Waitlist arms of the trial, and we
work with the families to identify or exclude any sources of pain and irritability through structured
history taking, physical examination, laboratory investigations and pharmacological interventions.
We cannot always identify the source of pain using the PIUO Pathway. Moreover, in children with
complex neurological conditions, pain and irritability are not always due to disease or injury, but
instead may be due to generalized irritability of the central nervous system. Kids that are still
experiencing PIUO after going through the Pathway are eligible to participate in our drug trial, which
investigates the efficacy of gabapentin in relieving PIUO. Gabapentin was originally used as an antiseizure medication, but has since become more known as an effective treatment for chronic,
complex pain. We hope that gabapentin can be proven to be beneficial in relieving these kids’ pain,
the nature of which we still do not fully understand.
|
| Genre | |
| Type | |
| Language |
eng
|
| Date Available |
2021-06-14
|
| Provider |
Vancouver : University of British Columbia Library
|
| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
| DOI |
10.14288/1.0398350
|
| URI | |
| Affiliation | |
| Peer Review Status |
Unreviewed
|
| Scholarly Level |
Faculty; Researcher; Graduate
|
| Rights URI | |
| Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International