Open Collections

UBC Faculty Research and Publications

An Update on Self-Amplifying mRNA Vaccine Development Blakney, Anna K.; Ip, Shell; Geall, Andrew J.

Abstract

This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.

Item Metadata

Title
An Update on Self-Amplifying mRNA Vaccine Development
Creator
Blakney, Anna K.; Ip, Shell; Geall, Andrew J.
Contributor
Michael Smith Laboratories
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2021-01-28
Description
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.
Subject
RNA; self-amplifying RNA; replicon; vaccine; drug delivery
Genre
Article
Type
Text
Language
eng
Date Available
2021-02-26
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0395980
URI
http://hdl.handle.net/2429/77401
Affiliation
Applied Science, Faculty of; Other UBC; Non UBC; Biomedical Engineering, School of
Citation
Vaccines 9 (2): 97 (2021)
Publisher DOI
10.3390/vaccines9020097
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

CC BY 4.0